CD4 T细胞在生命不同阶段的免疫保护中发挥着显着作用。在衰老过程中，机体内外环境与CD4 T细胞相互作用，导致CD4 T细胞库发生一系列变化，参与免疫衰老。许多研究广泛研究了免疫系统内 CD4 T 细胞的亚群和功能，强调了它们在疾病发病机制、进展和治疗干预中的关键作用。然而，CD4 T 细胞衰老的潜在机制及其与疾病的复杂关系仍有待阐明和全面了解。通过总结CD4 T细胞亚群的免疫衰老进展和网络，我们揭示了CD4 T细胞在年龄相关疾病发生和发展中的关键作用。此外，我们为以 CD4 T 细胞亚群衰老为治疗重点的疾病提供了新的见解和理论基础，提供了新的治疗方法，特别是在感染、癌症、自身免疫性疾病和其他老年疾病方面。© 2024 ）。衰老细胞由解剖学会和约翰·威利出版

CD4+T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4+T cells results in a series of changes in the CD4+T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4+T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions. However, the underlying mechanism of CD4+T cells senescence and its intricate association with diseases remains to be elucidated and comprehensively understood. By summarizing the immunosenescent progress and network of CD4+T cell subsets, we reveal the crucial role of CD4+T cells in the occurrence and development of age-related diseases. Furthermore, we provide new insights and theoretical foundations for diseases targeting CD4+T cell subsets aging as a treatment focus, offering novel approaches for therapy, especially in infections, cancers, autoimmune diseases, and other diseases in the elderly.© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.