众所周知，多形性胶质母细胞瘤（GBM）的精确定位如何预测肿瘤在周围神经元结构中的扩散方向。本综述的目的是通过评估 GBM 经常出现的解剖区域以及在不同大脑区域观察到的主要分子变化来揭示 GBM 的偏侧化。根据文献，GBM 的精确或最常见的侧化尚未确定。然而，可以说 GBM 在额叶中更常见。 GBM 涉及的束和束似乎集中在皮质脊髓束、上纵 I、II 和 III 束、弓状束长段、额海峡束和下额枕束。考虑到 GBM 的解剖特征及其大脑受累，顺理成章的是，主要受累的大脑区域分别是额叶-颞叶-顶叶-枕叶。尽管右半球的肿瘤体积较大，但已确定左半球诊断出癌症的患者预后较差，这可能反映了一些有害改变的解剖分布，例如 TP53 突变、PTEN 缺失、EGFR 扩增和MGMT 启动子甲基化。有理论指出，右半球在发育过程中较少受到外部影响，因为它负责生存所需的功能，而左半球的肿瘤可能更具侵袭性。为了阐明不同脑区 GBM 的具体解剖学和分子特征，本综述文章旨在描述与脑肿瘤发展相关的主要偏侧化途径以及基因突变或表观遗传修饰。

It is well known how the precise localization of glioblastoma multiforme (GBM) predicts the direction of tumor spread in the surrounding neuronal structures. The aim of the present review is to reveal the lateralization of GBM by evaluating the anatomical regions where it is frequently located as well as the main molecular alterations observed in different brain regions. According to the literature, the precise or most frequent lateralization of GBM has yet to be determined. However, it can be said that GBM is more frequently observed in the frontal lobe. Tractus and fascicles involved in GBM appear to be focused on the corticospinal tract, superior longitudinal I, II and III fascicles, arcuate fascicle long segment, frontal strait tract, and inferior fronto‑occipital fasciculus. Considering the anatomical features of GBM and its brain involvement, it is logical that the main brain regions involved are the frontal‑temporal‑parietal‑occipital lobes, respectively. Although tumor volumes are higher in the right hemisphere, it has been determined that the prognosis of patients diagnosed with cancer in the left hemisphere is worse, probably reflecting the anatomical distribution of some detrimental alterations such as TP53 mutations, PTEN loss, EGFR amplification, and MGMT promoter methylation. There are theories stating that the right hemisphere is less exposed to external influences in its development as it is responsible for the functions necessary for survival while tumors in the left hemisphere may be more aggressive. To shed light on specific anatomical and molecular features of GBM in different brain regions, the present review article is aimed at describing the main lateralization pathways as well as gene mutations or epigenetic modifications associated with the development of brain tumors.