与年龄相关的神经退行性疾病，如阿尔茨海默病 (AD)，对于那些无法治愈且治疗选择有限的患者来说是一种具有挑战性的疾病。代表散发性 AD (sAD) 的不同遗传背景和细胞亚型的功能性人类脑组织是有限的。人类干细胞衍生的大脑类器官概括了人类大脑细胞结构和 AD 样病理学的一些特征，为阐明 AD 病理学和导致认知能力下降的神经细胞失调之间的关系提供了一种工具。在这篇综述中，我们探讨了当前在 AD 研究中实施脑类器官的策略，以及使用类器官模型研究与年龄相关的脑部疾病相关的挑战。版权所有 © 2024 Fernandes、Revana、Pratt、Hayes、Marchetto 和 Gage。

Age-related neurodegenerative diseases, like Alzheimer's disease (AD), are challenging diseases for those affected with no cure and limited treatment options. Functional, human derived brain tissues that represent the diverse genetic background and cellular subtypes contributing to sporadic AD (sAD) are limited. Human stem cell derived brain organoids recapitulate some features of human brain cytoarchitecture and AD-like pathology, providing a tool for illuminating the relationship between AD pathology and neural cell dysregulation leading to cognitive decline. In this review, we explore current strategies for implementing brain organoids in the study of AD as well as the challenges associated with investigating age-related brain diseases using organoid models.Copyright © 2024 Fernandes, Revanna, Pratt, Hayes, Marchetto and Gage.