一名 79 岁男性出现与纵隔肿块和胸腔积液相关的呼吸窘迫，并被诊断为成人 T 细胞白血病/淋巴瘤。该患者从发病时起就对抗癌药物和放射治疗高度耐药，并且呼吸系统进行性恶化。然而，服用valemetostat 11天后，他的病情变得稳定，随后的低剂量抗癌药物导致病情迅速好转，并伴有高烧和C反应蛋白激增。在这种情况下，valemetostat 对肿瘤细胞的体内启动效应可能增加了这些细胞对传统抗癌药物的敏感性。© 2024 作者。 eJHaem 由英国血液学会和 John Wiley 出版

A 79-year-old man presented with respiratory distress associated with a mediastinal mass and pleural effusion, and was diagnosed as having adult T-cell leukemia/lymphoma. The patient was highly refractory to anticancer drugs and radiotherapy from the time of onset and had progressive respiratory deterioration. However, his condition became stable with the administration of valemetostat for 11 days, and subsequent low-dose-anticancer agents led to a rapid improvement accompanied by high fever and a surge in C-reactive protein. In this case, the in vivo priming effect of valemetostat on tumor cells may have increased the sensitivity of these cells to conventional anti-cancer drugs.© 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.