铁死亡是由铁依赖性致命脂质过氧化驱动的一种独特形式的受调节细胞死亡，与各种应激相关疾病有关，如神经退行性变、血管病变和代谢紊乱。与压力相关的疾病包括受压力影响或加剧的广泛的医学疾病。这些压力源可以表现在各种器官或组织系统中，并对人类的整体健康产生重大影响。了解这些疾病中的铁死亡为针对相关途径的治疗策略提供了见解。这篇综述探讨了铁死亡的机制、其在病理生理学中的作用、其与应激相关疾病的联系，以及铁死亡靶向纳米药物在治疗疾病中的潜力。该专着还深入研究了针对铁死亡的纳米药物工程，用于治疗与压力相关的疾病，包括癌症、心脑血管、神经退行性疾病、代谢和炎症疾病。无论如何，针对铁死亡的纳米疗法有望通过促进和抑制铁死亡来治疗与压力相关的疾病。© 2024 Kang 等人。

Ferroptosis, a unique form of regulated cell death driven by iron-dependent lethal lipid peroxidation, is implicated in various stress-related diseases like neurodegeneration, vasculopathy, and metabolic disturbance. Stress-related diseases encompass widespread medical disorders that are influenced or exacerbated by stress. These stressors can manifest in various organ or tissue systems and have significant implications for human overall health. Understanding ferroptosis in these diseases offers insights for therapeutic strategies targeting relevant pathways. This review explores ferroptosis mechanisms, its role in pathophysiology, its connection to stress-related diseases, and the potential of ferroptosis-targeted nanomedicines in treating conditions. This monograph also delves into the engineering of ferroptosis-targeted nanomedicines for tackling stress-related diseases, including cancer, cardia-cerebrovascular, neurodegenerative, metabolic and inflammatory diseases. Anyhow, nanotherapy targeting ferroptosis holds promise by both promoting and suppressing ferroptosis for managing stress-related diseases.© 2024 Kang et al.