继发转移占癌症相关死亡的 90%，对癌症治疗提出了巨大的挑战，其中骨转移是最常见的部位。重要的是，即使在成功根除原发肿瘤后，肿瘤也可能会复发，通常在骨骼中，这表明肿瘤细胞可能会在骨内休眠很长一段时间。这篇综述总结了肿瘤细胞休眠机制以及骨细胞在此过程中的作用的最新发现。骨骼中的造血干细胞 (HSC) 生态位为理解调控微环境提供了一个模型。休眠肿瘤细胞已被证明利用类似的生态位，有证据表明，通过 CXCL12-CXCR4、整合素和 TAM 受体信号传导，特别是通过 GAS6-AXL 与成骨细胞谱系细胞和其他基质细胞相互作用，导致休眠，并退出休眠可能受到破骨细胞骨吸收和神经信号传导的调节。全面了解休眠肿瘤细胞生态位及其调控机制对于开发靶向疗法至关重要，这是根除转移性肿瘤和阻止疾病复发的关键一步。© 2024 由 Elsevier GmbH 出版。

Secondary metastases, accounting for 90 % of cancer-related deaths, pose a formidable challenge in cancer treatment, with bone being a prevalent site. Importantly, tumours may relapse, often in the skeleton even after successful eradication of the primary tumour, indicating that tumour cells may lay dormant within bone for extended periods of time. This review summarises recent findings in the mechanisms underlying tumour cell dormancy and the role of bone cells in this process. Hematopoietic stem cell (HSC) niches in bone provide a model for understanding regulatory microenvironments. Dormant tumour cells have been shown to exploit similar niches, with evidence suggesting interactions with osteoblast-lineage cells and other stromal cells via CXCL12-CXCR4, integrins, and TAM receptor signalling, especially through GAS6-AXL, led to dormancy, with exit of dormancy potentially regulated by osteoclastic bone resorption and neuronal signalling. A comprehensive understanding of dormant tumour cell niches and their regulatory mechanisms is essential for developing targeted therapies, a critical step towards eradicating metastatic tumours and stopping disease relapse.© 2024 Published by Elsevier GmbH.