人类 G-CSF 四十年：一段短暂的历史。
Forty years of human G-CSF: A short history in time.
发表日期：2024 Aug 19
作者：
Karl Welte
来源：
BRITISH JOURNAL OF HAEMATOLOGY
摘要：
人类 G-CSF 于 1984 年在纽约纪念斯隆-凯特琳癌症中心被鉴定出来。基于这些发现，千橡市的安进公司开发了重组 G-CSF。 1987 年，临床试验开始在化疗后的癌症患者中使用重组 G-CSF，以缩短中性粒细胞减少症的持续时间，并在先天性中性粒细胞减少症 (CN) 患者中使用重组 G-CSF，以增加中性粒细胞的数量。它改变了许多癌症患者的生活质量，并挽救了许多癌症患者的生命。© 2024 作者。英国血液学杂志由英国血液学会和约翰·威利出版
Human G-CSF was identified in 1984 at Memorial Sloan-Kettering Cancer Centre, New York. Based on these findings, recombinant G-CSF was developed by Amgen, Thousand Oaks. In 1987, clinical trials began using recombinant G-CSF in cancer patients following chemotherapy to reduce the duration of neutropenia and in patients with congenital neutropenia (CN) to increase the number of neutrophils. It has changed the quality of life for many cancer patients and saved the lives of many patients with (CN).© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.