神经鞘瘤是一种罕见的间叶性肿瘤。在这项研究中，我们分析了 99 例神经鞘瘤的临床病理学。这项回顾性研究深入研究了腹部神经鞘瘤的临床、病理和免疫组织化学维度。对 99 例病例（包括 4 例恶性神经鞘瘤和 95 例良性神经鞘瘤）进行了仔细检查。临床分析显示显着的性别分布（男对女 1:1.7），平均年龄为 58.5 岁。大多数病例没有症状。对 99 例病例进行了仔细检查，其中包括 4 例恶性神经鞘瘤和 95 例良性神经鞘瘤。临床分析显示显着的性别分布（男对女 1:1.7），平均年龄为 58.5 岁。大多数病例没有症状。肿瘤大小范围为 0.5 至 30 厘米，大多数良性肿瘤的不同位置位于胃部，而恶性肿瘤则位于腹部/小肠。最初的误诊很常见。病理学评估揭示了良性神经鞘瘤的独特特征，包括 Antoni A 和 B 型、梭形细胞和淋巴鞘结构。恶性病例表现出非典型细胞、溃疡和侵袭性生长。免疫组织化学标记物，如 S100、SOX10 和波形蛋白，通过有助于准确的诊断而始终表现出阳性结果。治疗结果表明恶性病例预后不良，总生存期为 10 至 41 个月。相反，良性病例尽管行为不典型，但在随访期间未表现出复发或转移。这项研究强调了腹部神经鞘瘤的罕见性，并强调了全面诊断形态学和免疫组织化学的必要性。 SOX10 成为准确诊断的关键且特异的标记物。进一步的研究必须完善诊断方案并增强我们对腹部神经鞘瘤临床行为的理解。© 2024 作者。约翰·威利出版的癌症医学

Schwannoma is a rare mesenchymal tumor. In this study, we analyzed clinicopathologically 99 schwannomas.This retrospective study delves into the clinical, pathological, and immunohistochemical dimensions of abdominal schwannomas.A cohort of 99 cases, comprising 4 malignant and 95 benign schwannomas, was meticulously examined. Clinical analysis revealed a notable gender distribution (1:1.7, male to female) and an average age of 58.5 years. The majority of cases were asymptomatic. A cohort of 99 cases, comprising 4 malignant and 95 benign schwannomas, was meticulously examined. Clinical analysis revealed a notable gender distribution (1:1.7, male to female) and an average age of 58.5 years. The majority of cases were asymptomatic. Tumor sizes ranged from 0.5 to 30 cm, with distinct locations in the stomach for most benign cases and the abdomen/small intestine for malignancies. Initial misdiagnoses were frequent. Pathological evaluations revealed distinct features, including Antoni A and B patterns, spindle cells, and lymphatic sheath structures in benign schwannomas. Malignant cases exhibited atypical cells, ulcers, and invasive growth. Immunohistochemical markers, such as S100, SOX10, and vimentin, consistently demonstrated positivity by contributing to accurate diagnoses. Treatment outcomes indicated a poor prognosis in malignant cases, with overall survival ranging from 10 to 41 months. Conversely, benign cases displayed no recurrence or metastasis during follow-up, despite atypical behaviors.This study underscores the rarity of abdominal schwannomas and underscores the need for a comprehensive diagnostic morphology and immunohistochemistry. SOX10 emerges as a crucial and specific marker for accurate diagnosis. Further research is imperative to refine diagnostic protocols and enhance our understanding of the clinical behavior of abdominal schwannomas.© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.