Oncotype DX 前列腺基因组评分 (ODX-GPS) 是一种预测疾病侵袭性的基因表达测定。本研究的目的是确定与 ODX-GPS 摄取相关的社会人口统计学和区域因素。数据来自流行病学监测和最终结果登记，对象是患有局限性前列腺癌的男性，格里森评分为 3 3 或 3 4，PSA ≤ 20 ng/mL ，以及 2013 年至 2017 年 T1c 至 T2c 疾病阶段与 ODX-GPS 数据相关联。使用综合社会经济得分构建了人口普查区水平的邻里社会经济地位（nSES）五分位数。使用多变量逻辑回归来估计 ODX-GPS 摄取与诊断年龄、种族和民族、nSES、地理区域、保险类型和婚姻状况的关联，并考虑国家综合癌症网络风险组、诊断年份和聚类按人口普查区划分。在 111,434 名符合条件的男性中，5.5% 接受了 ODX-GPS 测试。其中，78.3% 为非西班牙裔白人，9.6% 为黑人，6.7% 为西班牙裔，3.6% 为亚裔美国人。黑人男性采用 ODX-GPS 的几率最低（优势比，0.70；95% 置信区间 [CI]，0.63-0.76）。 nSES 最高和最低五分位数的人采用 ODX-GPS 的可能性高出 1.64 倍（95% CI，1.38-2.94）。与南方相比，居住在东北部、西部和中西部的男性采用 ODX-GPS 的几率在统计学上显着更高。不同种族、族裔、nSES 和地理区域的 ODX-GPS 采用率存在差异。应共同努力确保该临床测试的公平性。© 2024 美国癌症协会。

The Oncotype DX Genomic Prostate Score (ODX-GPS) is a gene expression assay that predicts disease aggressiveness. The objective of this study was to identify sociodemographic and regional factors associated with ODX-GPS uptake.Data from Surveillance Epidemiology and End Results registries on men with localized prostate cancer with a Gleason score of 3 + 3 or 3 + 4, PSA ≤20 ng/mL, and stage T1c to T2c disease from 2013 through 2017 were linked with ODX-GPS data. Census-tract level neighborhood socioeconomic status (nSES) quintiles were constructed using a composite socioeconomic score. Multivariable logistic regression was used to estimate the associations of ODX-GPS uptake with age at diagnosis, race and ethnicity, nSES, geographic region, insurance type, and marital status, accounting for National Comprehensive Cancer Network risk group, year of diagnosis, and clustering by census tract.Among 111,434 eligible men, 5.5% had ODX-GPS test uptake. Of these, 78.3% were non-Hispanic White, 9.6% were Black, 6.7% were Hispanic, and 3.6% were Asian American. Black men had the lowest odds of ODX-GPS uptake (odds ratio, 0.70; 95% confidence interval [CI], 0.63-0.76). Those in the highest versus lowest quintile of nSES were 1.64 times more likely (95% CI, 1.38-2.94) to have ODX-GPS uptake. The odds of ODX-GPS uptake were statistically significantly higher among men residing in the Northeast, West, and Midwest compared to the South.Disparities in ODX-GPS uptake by race, ethnicity, nSES, and geographical region were identified. Concerted efforts should be made to ensure that this clinical test is equitably available.© 2024 American Cancer Society.