慢性疾病，特别是癌症、心血管疾病和骨骼疾病的出现提出了巨大的挑战，因为目前可用的合成药物往往会导致显着的副作用并产生更高的成本。植物雌激素 Bavachin 存在于补骨脂植物中，其结构和功能与哺乳动物雌激素相似，最近因其药用特性而吸引了研究人员的关注。这篇综述重点介绍了 Bavachin 的提取方法、生物利用度和针对疾病的治疗干预措施。 Bavachin 具有雌激素特性，能够与雌激素受体 (ER) 结合，模仿人类雌激素的作用并启动雌激素反应途径。 Bavachin 通过靶向信号转导、管理钙信号传导、免疫调节、炎症、细胞凋亡和氧化应激，在消除慢性疾病方面提供了有效的治疗方案，包括癌症、神经元、骨骼、心血管、皮肤、肺和肝脏疾病。计算机分析，包括基因本体和通路富集分析，检索 Bavachin 的分子靶标，主要是细胞色素 C 氧化酶 (COX)、活化 B 细胞的核因子 kappa 轻链增强子 (NF-κB)、核苷酸结合域、富含亮氨酸的家族、pyrin 结构域 3 (NLRP3) 和 ER，推测 Bavachin 预防重要健康疾病的细胞机制。还总结了 Bavachin 的局限性，具体剂量水平的肝毒性证明了这一点。总之，Bavachin 在抑制慢性疾病方面显示出有希望的治疗效果，可以被认为是激素替代疗法的充分替代品，需要对其有效性、安全性和临床结果进行进一步研究。© 2024。作者，拥有独家许可施普林格自然 B.V.

The emergence of chronic diseases, particularly cancers, cardiovascular, and bone disorders, presents a formidable challenge, as currently available synthetic drugs often result in significant side effects and incur higher costs. Phytoestrogen Bavachin, present in the Psoralea corylifolia L. plant, represents structural and functional similarity to mammalian estrogen and has recently attracted researchers for its medicinal properties. This review spotlighted the extraction methods, bioavailability and therapeutic interventions of Bavachin against diseases. Bavachin exerted estrogenic properties, demonstrating the ability to bind to estrogen receptors (ERs), mimicking the actions of human estrogen and initiating estrogen-responsive pathways. Bavachin delivered potent therapeutic ventures in abrogating chronic diseases, including cancer, neuronal, bone, cardiovascular, skin, lung, and liver disorders via targeting signaling transductions, managing calcium signaling, immune regulation, inflammation, apoptosis, and oxidative stress. In-silico analysis, including Gene ontology and pathway enrichment analysis, retrieved molecular targets of Bavachin, majorly cytochrome c oxidase (COX), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3), and ER, hypothesizing Bavachin's cellular mechanism in preventing crucial health ailments. Limitations of Bavachin were also summarized, evidenced by hepatotoxicity at specific dosage levels. In conclusion, Bavachin showed promising therapeutic efficacy in suppressing chronic diseases and can be considered as an adequate replacement for hormone replacement therapy, necessitating further investigations on its effectiveness, safety, and clinical outcomes.© 2024. The Author(s), under exclusive licence to Springer Nature B.V.