心脏毒性是当今癌症患者面临的严峻挑战。心脏毒性涉及多种因素。环状RNA（circRNA）是心脏毒性发生和预防的有效因素之一。 circRNA可以通过调节分子途径以及增加或减少基因表达来导致心肌细胞增殖、凋亡和再生增加；一些circRNA在心肌细胞再生或死亡中具有双重作用。识别与这些过程相关的每条途径可以有效地管理患者和预防心脏毒性。在本研究中，概述了 circRNA 参与心脏毒性的分子途径及其对下游因素的影响。© 2024。作者获得 Springer Science Business Media, LLC（Springer Nature 旗下子公司）的独家许可。

Cardiotoxicity is a serious challenge cancer patients face today. Various factors are involved in cardiotoxicity. Circular RNAs (circRNAs) are one of the effective factors in the occurrence and prevention of cardiotoxicity. circRNAs can lead to increased proliferation, apoptosis, and regeneration of cardiomyocytes by regulating the molecular pathways, as well as increasing or decreasing gene expression; some circRNAs have a dual role in cardiomyocyte regeneration or death. Identifying each of the pathways related to these processes can be effective on managing patients and preventing cardiotoxicity. In this study, an overview of the molecular pathways involved in cardiotoxicity by circRNAs and their effects on the downstream factors have been discussed.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.