我们试图评估接受蒽环类药物治疗的青少年和青年儿童癌症幸存者中传统和新型超声心动图测量右心室 (RV) 收缩功能的可行性、可重复性和准确性。超声心动图和心脏磁共振成像 (CMR) 采集≤60前瞻性招募的幸存者相隔数天，RV 功能测量由盲人观察者进行定量。在一个子集中进行重复定量以评估再现性。对于每项超声心动图测量，计算 Spearman 与 CMR 测量的相关性，并使用两个样本 Wilcoxon 秩和检验比较 CMR RV 射血分数 (RVEF) ≥48% 和 RVEF <48% 的参与者的值。 在 58 名参与者中，平均年龄年龄为 18.2 岁（范围 13.1-25.2），五名参与者的 CMR RVEF <48%。调整后的自动应变测量的观察者内和观察者间的变异系数分别为 8.2%-10.1% 和 10.5%-12.0%，3D RVEF 的变异系数分别为 5.2%-8.7% 和 2.7%。超声心动图测量结果与 CMR RVEF 没有显着相关性；只有三尖瓣环平面收缩期偏移与 CMR RV 每搏输出量相关 (r = .392，p = .003)。右心室功能障碍的参与者的自动整体纵向应变（-20.3% vs. -23.9%，p = .007）和游离壁纵向应变（-23.7% vs. -26.7%，p = .09）较差。超声心动图应变和 3D右心室功能测量对于高危儿童癌症幸存者来说是可行且可重复的。尽管在右心室功能主要正常的人群中，CMR RVEF 与 CMR RVEF 无关，但在右心室功能障碍的参与者中，自动应变测量结果更为异常，这表明这些措施具有潜在的临床实用性。© 2024 作者。超声心动图由 Wiley periodicals LLC 出版。

We sought to assess the feasibility, reproducibility, and accuracy of conventional and newer echocardiographic measures of right ventricular (RV) systolic function in adolescent and young adult childhood cancer survivors treated with anthracyclines.Echocardiography and cardiac magnetic resonance imaging (CMR) were acquired ≤60 days apart in prospectively recruited survivors and RV functional measures were quantitated by blinded observers. Repeat quantitation was performed in a subset to evaluate reproducibility. For each echocardiographic measure, Spearman correlations with CMR measures were calculated, and values in participants with CMR RV ejection fraction (RVEF) ≥48% and RVEF <48% were compared using two sample Wilcoxon rank-sum tests.Among 58 participants, mean age was 18.2 years (range 13.1-25.2) and five participants had CMR RVEF <48%. Intra- and inter-observer coefficients of variation were 8.2%-10.1% and 10.5%-12.0% for adjusted automated strain measures, and 5.2%-8.7% and 2.7% for 3D RVEF, respectively. No echocardiographic measures were significantly correlated with CMR RVEF; only tricuspid annular plane systolic excursion was correlated with CMR RV stroke volume (r = .392, p = .003). Participants with RV dysfunction had worse automated global longitudinal strain (-20.3% vs. -23.9%, p = .007) and free wall longitudinal strain (-23.7% vs. -26.7%, p = .09).Echocardiographic strain and 3D RV function measurements were feasible and reproducible in at-risk childhood cancer survivors. Although not associated with CMR RVEF in this population with predominantly normal RV function, automated strain measurements were more abnormal in participants with RV dysfunction, suggesting potential clinical utility of these measures.© 2024 The Author(s). Echocardiography published by Wiley Periodicals LLC.