与大多数儿童癌症不同，ALL 的治疗包括长期的维持阶段，在此期间儿童通常会恢复正常活动。医生需要有关 COVID-19 对该人群的持续影响的数据，以帮助指导大流行后的家庭。儿科肿瘤 COVID-19 病例报告 (POCC) 收集去识别化数据（社会人口统计学、临床数据 [癌症、COVID-19 课程]）来自 104 个美国儿科肿瘤机构的儿童、青少年和年轻人患有癌症和 COVID-19。本文介绍的分析将患有 ALL 维持治疗 (ALL-MTN) 的儿童（≤21 岁）与所有其他患有癌症和 COVID-19 的儿童进行了比较。多变量分析根据年龄、种族/族裔、保险、感染时的绝对中性粒细胞计数、疫苗接种和合并症进行调整。与报告给 POCC 的其他儿童 (n = 1,190) 相比，ALL-MTN 中的儿童 (n = 481)较少住院 (23% vs 29%, P = .01) 或住进重症监护室 (ICU: 3% vs 5%, P = .01)；这些结果在多变量分析中得到了证实（住院：比值比 [OR]，0.7 [95% CI，0.6 至 0.9]；ICU：OR，0.5 [95% CI，0.2 至 0.8]）。然而，对于 ALL-MTN 儿童，癌症导向治疗的改变更为频繁（50% vs 33%，P ≤ .01；OR，2.0 [95% CI，1.6 至 2.5]）。在我们的多变量模型中，疫苗接种是一个独立的预后因素，可降低住院几率（OR，0.7 [95% CI，0.5 至 0.9]）。ALL-MTN 中的儿童比其他癌症儿童需要更少的住院治疗和 ICU 入院，但需要更多的治疗调整。接种 COVID-19 疫苗可降低住院几率。

Unlike most childhood cancers, therapy for ALL includes a prolonged maintenance phase during which children typically resume regular activities. Physicians need data regarding the persistent impact of COVID-19 in this population to help guide families after the pandemic.The Pediatric Oncology COVID-19 Case Report (POCC) collects deidentified data (sociodemographics, clinical data [cancer, COVID-19 course]) on children, adolescents, and young adults with cancer and COVID-19 from 104 US pediatric oncology institutions. The analysis presented here compares children (≤21 years) with ALL in maintenance (ALL-MTN) with all other children with cancer and COVID-19. Multivariable analyses adjust for age, race/ethnicity, insurance, absolute neutrophil count at the time of infection, vaccination, and comorbidities.Compared with other children reported to POCC (n = 1,190), those in ALL-MTN (n = 481) were less often hospitalized (23% v 29%, P = .01) or admitted to the intensive care unit (ICU: 3% v 5%, P = .01); these findings persisted in multivariable analysis (hospitalization: odds ratio [OR], 0.7 [95% CI, 0.6 to 0.9]; ICU: OR, 0.5 [95% CI, 0.2 to 0.8]). However, cancer-directed therapy was changed more often for children in ALL-MTN (50% v 33%, P ≤ .01; OR, 2.0 [95% CI, 1.6 to 2.5[). Vaccination was an independent prognostic factor in our multivariable model, decreasing odds of hospitalization (OR, 0.7 [95% CI, 0.5 to 0.9]).Children in ALL-MTN required fewer hospitalizations and ICU admissions but more therapy modifications than other children with cancer. Vaccination against COVID-19 reduced the odds of hospitalization.