卵巢癌与延迟诊断和生存率低有关；因此，人们对识别预测和预后生物标志物以及新型治疗剂非常感兴趣。尽管随着更新、更有效但更昂贵的治疗方案的出现，卵巢癌的护理费用可能会增加，但目前卵巢癌护理费用的信息（从诊断到生命终结的整个护理过程）仍然缺乏.本研究旨在根据患者的护理阶段、年龄、种族/民族和地理区域，估计诊断后前 5 年内卵巢癌护理的实际平均和中位费用。我们对卵巢癌进行了回顾性队列研究2015 年 1 月 1 日至 2020 年 12 月 31 日之间诊断的患者。我们使用来自 Optum 去识别化的 Clinformatics® Data Mart 数据库的索赔数据，其中包括全国商业保险和医疗保险受益人的住院、门诊和处方索赔。卵巢癌护理的费用是根据开始护理（即前 6 个月）、持续护理（即初始护理和临终护理之间的时期）和临终护理（即过去 6 个月）阶段并以 2021 年美元金额报告。卵巢癌护理费用按年龄、种族/民族和地理区域分层。由于成本数据的倾斜性质，平均成本数据经过对数转换以进行建模。对对数成本进行普通最小二乘回归，并根据患者分类年龄、种族/族裔和地理区域进行调整。分析中总共包括 7913 名患者。卵巢癌护理的每年平均费用在护理开始期间为 > 200,000 美元，在持续护理阶段为 26,000 至 88,000 美元，在临终护理阶段为 > 129,000 美元。在每个护理阶段，年龄和费用之间存在统计学上显着的关联。与年轻患者相比，老年患者在持续护理阶段的费用较高，在临终护理阶段的费用较低。无论护理阶段如何，卵巢癌护理费用的地理差异也很明显。在我们的队列中，费用和种族/民族之间没有关联。卵巢癌护理费用很高，并且根据护理阶段、年龄类别和地理区域的不同而有所不同。随着更有效但更昂贵的卵巢癌治疗方案的出现以及潜在的生存获益，在整个癌症护理过程中将需要可持续的干预措施来降低卵巢癌的护理成本。版权所有 © 2024。由爱思唯尔公司出版。

Ovarian cancer is associated with delayed diagnosis and poor survival; thus, interest is high in identifying predictive and prognostic biomarkers and novel therapeutic agents. Although the costs of ovarian cancer care are likely to increase as newer, more effective, but more expensive treatment regimens become available, information on the current costs of care for ovarian cancer-across the care continuum from diagnosis to the end of life-are lacking.This study aimed to estimate real-world mean and median costs of ovarian cancer care within the first 5 years after diagnosis by patients' phase of care, age, race/ethnicity, and geographic region.We performed a retrospective cohort study of ovarian cancer patients diagnosed between January 1, 2015 and December 31, 2020. We used claims data from Optum's de-identified Clinformatics® Data Mart database, which includes inpatient, outpatient, and prescription claims for commercial insurance and Medicare beneficiaries nationwide. Cost of ovarian cancer care were calculated for the start of care (ie, the first 6 months), continuing care (ie, period between the initial and end-of-life care), and end-of-life care (ie, the last 6 months) phases and reported in 2021 U.S. dollar amounts. Ovarian cancer care costs were stratified by age, race/ethnicity, and geographic region. Due to the skewed nature of cost data, the mean cost data were log-transformed for modelling. Ordinary least-squares regression was conducted on the log costs, adjusting for patient categorical age, race/ethnicity, and geographic region.A total of 7913 patients were included in the analysis. The mean cost per year for ovarian cancer care was >$200,000 during the start of care, between $26,000 and $88,000 during the continuing care phase, and >$129,000 during the end-of-life care phase. There were statistically significant associations between age and costs during each phase of care. Compared to younger patients, older patients incurred higher costs during the continuing care phase and lower costs during the end-of-life care phase. Geographic differences in the costs of ovarian cancer care were also noted regardless of the phase of care. There were no associations between cost and race/ethnicity in our cohort.Ovarian cancer care costs are substantial and vary by the phase of care, age category, and geographic region. As more effective but expensive treatment options for ovarian cancer become available with potential survival benefit, sustainable interventions to reduce the cost of care for ovarian cancer will be needed throughout the cancer care continuum.Copyright © 2024. Published by Elsevier Inc.