含有三联基序的 24 (TRIM24)，也称为转录中间因子 1α (TIF1α)，是 TIF1 家族的创始成员。最近的证据表明，作为癌基因的 TRIM24 的异常表达与各种癌症类型的不良预后相关。 TRIM24 表现出多面结构，包括具有 RING 结构域的 N 端 TRIM 区域、1 型和 2 型 B 盒结构域、卷曲螺旋区域以及 C 端植物同源结构域 (PHD)-溴结构域。溴结构域充当表观遗传组蛋白标记的“阅读器”，通过将相关蛋白与乙酰化核小体靶标连接来调节染色质结构和基因表达，从而控制基因转录。值得注意的是，溴结构域已成为癌症治疗开发的引人注目的靶标。此外，TRIM24 作为信号转导分子发挥着特殊作用，在癌细胞中协调各种细胞信号级联反应。在此，我们回顾了了解 TRIM24 功能的最新进展，并展示了利用 TRIM24 作为癌症治疗靶点的研究进展。© 2024。作者。

Tripartite motif-containing 24 (TRIM24), also known as transcriptional intermediary factor 1α (TIF1α), is the founding member of TIF1 family. Recent evidence indicates that aberrant expression of TRIM24, functions as an oncogene, is associated with poor prognosis across various cancer types. TRIM24 exhibits a multifaceted structure comprising an N-terminal TRIM region with a RING domain, B-box type 1 and type 2 domains, and a coiled-coil region, as well as a C-terminal plant-homeodomain (PHD)-bromodomain. The bromodomain serves as a 'reader' of epigenetic histone marks, regulating chromatin structure and gene expression by linking associated proteins to acetylated nucleosomal targets, thereby controlling transcription of genes. Notably, bromodomains have emerged as compelling targets for cancer therapeutic development. In addition, TRIM24 plays specialized roles as a signal transduction molecule, orchestrating various cellular signaling cascades in cancer cells. Herein, we review the recent advancements in understanding the functions of TRIM24, and demonstrate the research progress in utilizing TRIM24 as a target for cancer therapy.© 2024. The Author(s).