在军事和民用环境中，许多创伤患者死于失血性休克。尽管三分之二的失血性休克患者死于失血以外的原因，例如随之而来的细胞因子风暴，但抗炎疗法未能得到利用。基于凋亡细胞的治疗增强了发挥全身免疫调节的先天能力，如一些临床应用所证明的那样，因此可能为失血性休克治疗提供一种新方法。22 只大鼠接受了压力控制失血性休克模型，并随访 24 小时。治疗组输注凋亡细胞（Allocetra-OTS，Enlivex Therapeutics Ltd，Nes Ziona，以色列）。将血流动力学、血细胞计数、生化结果和细胞因子谱与生理盐水复苏对照组进行比较。治疗组的平均动脉压从 94.8mmHg 降至 28.2mmHg，导致乳酸增加 8.13mg/dL，乳酸增加 1.9g/dL。 L血红蛋白减少，与对照组相似。治疗组的白细胞和血小板下降幅度更大。治疗组在出血后 24 小时后类似的细胞因子谱明显减弱。促炎细胞因子的水平，例如白细胞介素 (IL)-1a（28.4 pg/mL vs. 179.1 pg/mL）、IL-1b（47.4 pg/mL vs. 103.9 pg/mL）、IL-6（526.2 pg/mL）治疗组中，mL vs. 3492 pg/mL)、干扰素 γ (11.4 pg/mL vs. 427.9 pg/mL) 和肿瘤坏死因子 α (19.0 pg/mL vs. 31.7 pg/mL) 显着降低。在大鼠压力控制失血性休克模型中，凋亡细胞输注显示出均匀减弱的细胞因子反应的初步迹象。基于细胞凋亡的疗法可能作为失血性休克的新型免疫调节疗法。©美国军事外科医生协会 2024。保留所有权利。如需商业重复使用，请联系 reprints@oup.com 获取转载和转载的翻译权。所有其他权限都可以通过我们网站文章页面上的权限链接通过我们的 RightsLink 服务获得 - 欲了解更多信息，请联系journals.permissions@oup.com。

Many trauma patients die from hemorrhagic shock in the military and civilian settings. Although two-thirds of hemorrhagic shock victims die of reasons other than exsanguination, such as the consequent cytokine storm, anti-inflammatory therapies failed to be utilized. Apoptotic cell-based treatments enhance innate ability to exert systemic immunomodulation as demonstrated in several clinical applications and hence might present a novel approach in hemorrhagic shock treatment.Twenty-two rats underwent a pressure-controlled hemorrhagic shock model and followed up for 24 hours. An infusion of apoptotic cells (Allocetra-OTS, Enlivex Therapeutics Ltd, Nes Ziona, Israel) was administered to the treatment group. Hemodynamics, blood counts, biochemistry findings, and cytokine profile were compared to a saline-resuscitated control group.The treatment group's mean arterial pressure decreased from 94.8 mmHg to 28.2 mmHg, resulting in an 8.13 mg/dL increase in lactate and a 1.9 g/L decrease in hemoglobin, similar to the control group. White blood cells and platelets decreased more profoundly in the treatment group. A similar cytokine profile after 24 hours was markedly attenuated in the treatment group 2 hours after bleeding. Levels of pro-inflammatory cytokines such as interleukin (IL)-1a (28.4 pg/mL vs. 179.1 pg/mL), IL-1b (47.4 pg/mL vs. 103.9 pg/mL), IL-6 (526.2 pg/mL vs. 3492 pg/mL), interferon γ (11.4 pg/mL vs. 427.9 pg/mL), and tumor necrosis factor α (19.0 pg/mL vs. 31.7 pg/mL) were profoundly lower in the treatment group.In a pressure-control hemorrhagic shock model in rats, apoptotic cell infusion showed preliminary signs of a uniform attenuated cytokine response. Apoptotic cell-based therapies might serve as a novel immunomodulatory therapy for hemorrhagic shock.© The Association of Military Surgeons of the United States 2024. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.