化疗可以有效治疗癌症，但也会对心血管系统产生有害影响。本研究探讨了二甲双胍在减少化疗引起的心脏损伤方面的可能作用。在本次范围界定综述中，我们对电子数据库（PubMed、Scopus 和 Web of Science (ISI)）进行了全面的文献检索，直至 2023 年 11 月。手稿筛选了二甲双胍在化疗引起的心脏毒性中的作用。经过双重筛选，最终选出26篇论文。化疗有可能损害并导致心脏细胞死亡，与未治疗组相比，导致分子、生化和组织学的变化。然而，与二甲双胍联合治疗可以通过预防或逆转这些对心肌细胞的有害影响来提供保护。二甲双胍的心脏保护特性被认为是由于其调节氧化应激、炎症、自噬和细胞凋亡途径的能力。本研究强烈表明二甲双胍是治疗化疗引起的心脏毒性的有效解决方案。二甲双胍可以通过影响氧化应激、炎症、自噬和凋亡途径来减轻化疗对心脏的有害影响。然而，值得注意的是，二甲双胍的使用可能有一些缺点，因为它是一种非靶向疗法，可能会降低靶向抗癌药物的有效性。尽管如此，在临床环境中使用二甲双胍的潜在益处仍不容忽视。需要进一步的研究来确定这种相互作用的具体情况。尽管如此，本次综述的令人鼓舞的结果表明二甲双胍可能是对抗化疗引起的心脏毒性的重要工具。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Chemotherapy therapies are effective in treating cancer, but they can have harmful effects on the cardiovascular system. This study explores the possible role of metformin in reducing the cardiac damage caused by chemotherapy.In this scoping review, we conducted a comprehensive literature search on electronic databases (PubMed, Scopus, and Web of Science (ISI)) until November 2023. The manuscript was screened regarding the role of metformin in chemotherapy-induced cardiotoxicity. Finally, 26 papers were selected after double screening.Chemotherapy has the potential to damage and cause cell death in the heart, resulting in molecular, biochemical, and histological changes compared to an untreated group. However, co-treatment with metformin may offer protection by preventing or reversing these harmful effects on cardiac cells. Metformin's cardioprotective properties are thought to be due to its ability to modulate oxidative stress, inflammation, autophagy, and the apoptotic pathway.The present study strongly suggests that metformin is an effective solution to chemotherapy-induced cardiotoxicity. Metformin can alleviate the harmful effects of chemotherapy on the heart by affecting oxidative stress, inflammation, autophagy, and apoptosis pathways. However, it is essential to note that the use of metformin may have some drawbacks, as it is a non-targeted therapy and could potentially reduce the effectiveness of targeted cancer drugs. Despite this, the potential benefits of using metformin in clinical settings cannot be ignored. Further studies are necessary to determine the specifics of this interaction. Still, the promising results of this review suggest that metformin may be an essential tool in the fight against chemotherapy-induced cardiotoxicity.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.