子宫内膜是子宫极其重要的组成部分，对于个人健康和人类生殖至关重要。然而，传统方法仍难以理想地修复受损子宫内膜的结构和功能并恢复生育能力。因此，寻求和开发创新技术和材料有可能修复和再生受损或患病的子宫内膜。各种纳米医学和生物材料的出现和功能化，以及再生医学和组织工程技术的提出和发展，为解决这些问题带来了巨大的希望。在这篇综述中，我们将总结有助于子宫内膜再生的各种纳米医学、生物材料和创新技术，包括纳米级外泌体、纳米材料、干细胞基材料、天然来源的生物材料、化学合成的生物材料、生物材料功能化的途径和方法，以及随着类器官、器官芯片、人工智能等革命性新技术的应用，新型生物材料的多样化设计和修饰赋予其新的功能，如微结构或纳米结构、力学性能、生物功能、细胞功能等。微环境调节。将为子宫内膜的再生提供新的选择，为患者生殖能力的重建和恢复带来新的希望。© 2024 Liu et al.

The endometrium is an extremely important component of the uterus and is crucial for individual health and human reproduction. However, traditional methods still struggle to ideally repair the structure and function of damaged endometrium and restore fertility. Therefore, seeking and developing innovative technologies and materials has the potential to repair and regenerate damaged or diseased endometrium. The emergence and functionalization of various nanomedicine and biomaterials, as well as the proposal and development of regenerative medicine and tissue engineering techniques, have brought great hope for solving these problems. In this review, we will summarize various nanomedicine, biomaterials, and innovative technologies that contribute to endometrial regeneration, including nanoscale exosomes, nanomaterials, stem cell-based materials, naturally sourced biomaterials, chemically synthesized biomaterials, approaches and methods for functionalizing biomaterials, as well as the application of revolutionary new technologies such as organoids, organ-on-chips, artificial intelligence, etc. The diverse design and modification of new biomaterials endow them with new functionalities, such as microstructure or nanostructure, mechanical properties, biological functions, and cellular microenvironment regulation. It will provide new options for the regeneration of endometrium, bring new hope for the reconstruction and recovery of patients' reproductive abilities.© 2024 Liu et al.