表观遗传修饰影响基因表达并影响癌症的发生和进展。因此，它们可作为诊断和预后生物标志物以及潜在的治疗靶点。自然杀伤 (NK) 细胞是先天免疫系统的组成部分，通过激活和抑制配体的平衡识别和消除癌细胞，从而发挥抗肿瘤作用。了解 NK 细胞配体的表观遗传调控为增强 NK 细胞介导的肿瘤根除提供了见解。这篇综述探讨了控制激活 NKG2D 配体表达的表观遗传修饰，并讨论了研究基于 NK 细胞的免疫疗法的临床试验，强调了它们作为有效癌症治疗策略的潜力。案例研究检查了 NK 细胞疗法在不同癌症类型（例如急性髓系白血病 (AML) 和非小细胞肺癌 (NSCLC)）中的安全性和有效性，结果表明具有最小毒性的良好结果。这些发现强调了 NKG2D 配体表观遗传调节和基于 NK 细胞的免疫疗法作为有效癌症治疗策略的治疗前景。未来在个性化医疗方法和 NK 细胞联合疗法方面的研究将进一步改善治疗结果，并为治疗各种类型的癌症患者提供新的治疗选择。版权所有 © 2024 Kumar 和 Gupta。

Epigenetic modifications influence gene expression and effects cancer initiation and progression. Therefore, they serve as diagnostic and prognostic biomarkers and potential therapeutic targets. Natural Killer (NK) cells, integral to the innate immune system, exhibit anti-tumor effect by recognizing and eliminating cancerous cells through the balance of activating and inhibitory ligands. Understanding the epigenetic regulation of NK cell ligands offers insights into enhancing NK cell-mediated tumor eradication. This review explores the epigenetic modifications governing the expression of activating NKG2D ligands and discusses clinical trials investigating NK cell-based immunotherapies, highlighting their potential as effective cancer treatment strategies. Case studies examining the safety and effectiveness of NK cell therapies in different cancer types, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC), demonstrate promising outcomes with minimal toxicity. These findings underscore the therapeutic prospects of epigenetic modulation of NKG2D ligands and NK cell-based immunotherapies as effective cancer treatment strategies. Future research in the advancement of personalized medicine approaches and novel combination therapies with NK cell will further improve treatment outcomes and provide new therapeutic options for treating patients with various types of cancer.Copyright © 2024 Kumar and Gupta.