长链非编码RNA（lncRNA）在肿瘤，特别是胃肠道肿瘤中的作用已引起广泛关注。越来越多的证据强调了各种 lncRNA 和参与癌症进展的不同分子途径之间的相互作用。其中一个关键途径是 PI3K/AKT 途径，它是维持正常细胞生长和存活的各种细胞生理过程之间的平衡的重要细胞内机制。癌症中 PI3K/AKT 通路的频繁失调以及异常激活在驱动肿瘤发生中发挥着关键作用。 LncRNA 通过多种机制调节 PI3K/AKT 信号通路，主要通过充当竞争性内源 RNA 来调节 miRNA 表达和相关基因。这种相互作用显着影响细胞增殖、转移和耐药性等基本生物学行为。胃肠道肿瘤中多种lncRNA的异常表达通常与癌症患者的临床结果和病理特征相关。此外，这些lncRNA通过PI3K/AKT通路的异常激活影响多种类型胃肠道肿瘤中肿瘤细胞对化疗的敏感性。这些发现为了解胃肠道肿瘤的机制和潜在的治疗靶点提供了宝贵的见解。然而，胃肠道肿瘤仍然是一个重大的全球健康问题，近几十年来胃肠道肿瘤的发病率和死亡率不断增加。该综述全面总结了lncRNA与PI3K/AKT通路在胃肠道肿瘤发生发展中相互作用的最新研究成果。此外，重点关注lncRNA和PI3K/AKT通路在癌变中的功能，探索表达谱、临床病理特征、与PI3K/AKT通路的相互作用机制以及潜在的临床应用。版权所有©2024 Li、Ma和Gu。

The role of long noncoding RNA (lncRNA) in tumors, particularly in gastrointestinal tumors, has gained significant attention. Accumulating evidence underscores the interaction between various lncRNAs and diverse molecular pathways involved in cancer progression. One such pivotal pathway is the PI3K/AKT pathway, which serves as a crucial intracellular mechanism maintaining the balance among various cellular physiological processes for normal cell growth and survival. Frequent dysregulation of the PI3K/AKT pathway in cancer, along with aberrant activation, plays a critical role in driving tumorigenesis. LncRNAs modulate the PI3K/AKT signaling pathway through diverse mechanisms, primarily by acting as competing endogenous RNA to regulate miRNA expression and associated genes. This interaction significantly influences fundamental biological behaviors such as cell proliferation, metastasis, and drug resistance. Abnormal expression of numerous lncRNAs in gastrointestinal tumors often correlates with clinical outcomes and pathological features in patients with cancer. Additionally, these lncRNAs influence the sensitivity of tumor cells to chemotherapy in multiple types of gastrointestinal tumors through the abnormal activation of the PI3K/AKT pathway. These findings provide valuable insights into the mechanisms underlying gastrointestinal tumors and potential therapeutic targets. However, gastrointestinal tumors remain a significant global health concern, with increasing incidence and mortality rates of gastrointestinal tumors over recent decades. This review provides a comprehensive summary of the latest research on the interactions of lncRNA and the PI3K/AKT pathway in gastrointestinal tumor development. Additionally, it focuses on the functions of lncRNAs and the PI3K/AKT pathway in carcinogenesis, exploring expression profiles, clinicopathological characteristics, interaction mechanisms with the PI3K/AKT pathway, and potential clinical applications.Copyright © 2024 Li, Ma and Gu.