沙眼衣原体（C. trachomatis）与多种妇科肿瘤有关；但其在乳腺癌中的预后作用仍不清楚。因此，我们研究了抗 C 蛋白的预后作用。乳腺癌患者沙眼衣原体免疫球蛋白G（IgG）及其促炎细胞因子的修饰作用。检测血清沙眼衣原体IgG和4种促炎细胞因子的水平。使用Cox回归计算风险比（HR）和95％置信区间（CI），包括乘积术语来评估促炎细胞因子对沙眼衣原体IgG与乳腺癌预后之间关联的修改效果。2008年至2018年，招募了1121名乳腺癌患者并随访至2021年12月31日，中位随访时间为63.91个月（四分位距：39.16-90.08个月）。与阴性患者相比，沙眼衣原体 IgG 呈阳性的患者总生存期 (OS) 的 HR 为 1.09 (95% CI，0.67-1.78)，无进展生存期 (PFS) 的 HR 为 1.24 (0.87-1.78)。这些关联在 50 岁或以下的女性中变得具有统计学意义（OS 的 HR=1.43，95% CI=0.79-2.58；PFS 的 HR=1.79，95% CI=1.16-2.77）。沙眼衣原体 IgG 血清学阳性与促炎细胞因子（IL-6、TNF-α、IL-8 和 IL-1β）水平较高的患者的不良预后影响相关，但对于促炎细胞因子（IL-6、TNF-α、IL-8 和 IL-1β）水平较低的患者则具有良好的预后影响。水平。这些相互作用在 50 岁或以下的患者中尤其显着。在 50 岁以下或促炎细胞因子水平较高的乳腺癌患者中，沙眼衣原体感染似乎会对预后产生负面影响。这些发现强调了沙眼衣原体在预测乳腺癌患者预后和个性化治疗方面的重要性。© 2024 Li et al.

Chlamydia trachomatis (C. trachomatis) is associated with several gynecological tumors; yet its prognostic role in breast cancer remains unclear. Thus, we investigated the prognostic role of anti-C. trachomatis immunoglobulin G (IgG) in breast cancer patients and the modification effects of pro-inflammatory cytokines.The serum levels of C. trachomatis IgG and four pro-inflammatory cytokines were measured. Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), including product terms to assess the modification effects of pro-inflammatory cytokines on the association between C. trachomatis IgG and breast cancer prognosis.From 2008 to 2018, 1121 breast cancer patients were recruited and followed up until December 31, 2021, with a median follow-up time of 63.91 months (interquartile range: 39.16-90.08 months). Patients positive for C. trachomatis IgG showed HRs of 1.09 (95% CI, 0.67-1.78) for overall survival (OS) and 1.24 (0.87-1.78) for progression-free survival (PFS), compared to those who were negative. These associations became statistically significant in women aged 50 years or younger (HR=1.43, 95% CI=0.79-2.58 for OS; HR=1.79, 95% CI=1.16-2.77 for PFS). Positive C. trachomatis IgG serology was associated with adverse prognostic effects among patients with higher levels of pro-inflammatory cytokines (IL-6, TNF-α, IL-8, and IL-1β), but with favorable prognostic effects for those with low levels. These interactions were particularly significant in those aged 50 years or younger.In breast cancer patients younger than 50 years of age or with higher levels of pro-inflammatory cytokines, C. trachomatis infection appeared to have a negative prognostic impact. These findings highlight the significance of C. trachomatis in predicting prognosis and personalized therapy for breast cancer patients.© 2024 Li et al.