据报道，乳腺癌已超越肺癌，成为全世界女性最常诊断出的癌症。脂肪细胞作为能量储存和内分泌细胞，是乳房中的主要基质细胞。癌症相关脂肪细胞（CAA）是位于人类乳腺肿瘤侵袭性前沿的邻近且去分化的脂肪细胞。脂肪细胞在乳腺癌细胞的重塑下可转化为CAA表型，并发生形态和生物学变化。 CAAs 在乳腺癌进展中发挥着重要作用，包括重塑肿瘤微环境 (TME)、调节免疫以及与乳腺癌细胞相互作用。 CAA具有独特的分泌组，因此能够促进乳腺癌细胞的增殖、侵袭、血管生成、转移、免疫逃逸和耐药性。 CAA、免疫细胞和乳腺癌细胞之间存在复杂且协调的串扰。 CAAs可以释放多种细胞因子，包括IL-6、IL-8、IL-1β、CCL5、CCL2、VEGF、G-CSF、IGF-1和IGFBP，从而促进免疫细胞募集和巨噬细胞极化，最终刺激乳腺癌细胞的恶性行为。在这里，我们的目标是提供 CAA 衍生细胞因子的全面描述，包括它们对癌细胞行为、免疫调节、乳腺癌诊断和治疗的影响。更深入地了解 CAA 性能以及与特定 TME 细胞群的相互作用将为癌症治疗和乳房切除术后乳房重建提供更好的策略。© 2024 作者。

Breast cancer has been reported to transcend lung cancer as the most commonly diagnosed cancer in women all over the world. Adipocytes, serving as energy storage and endocrine cells, are the major stromal cells in the breast. Cancer-associated adipocytes (CAAs) are adjacent and dedifferentiated adipocytes located at the invasive front of human breast tumors. Adipocytes can transform into CAA phenotype with morphological and biological changes under the remodeling of breast cancer cells. CAAs play an essential role in breast cancer progression, including remodeling the tumor microenvironment (TME), regulating immunity, and interacting with breast cancer cells. CAAs possess peculiar secretomes and are accordingly capable to promote proliferation, invasiveness, angiogenesis, metastasis, immune escape, and drug resistance of breast cancer cells. There is a complex and coordinated crosstalk among CAAs, immune cells, and breast cancer cells. CAAs can release a variety of cytokines, including IL-6, IL-8, IL-1β, CCL5, CCL2, VEGF, G-CSF, IGF-1, and IGFBP, thereby promoting immune cell recruitment and macrophage polarization, and ultimately stimulating malignant behaviors in breast cancer cells. Here, we aim to provide a comprehensive description of CAA-derived cytokines, including their impact on cancer cell behaviors, immune regulation, breast cancer diagnosis, and treatment. A deeper understanding of CAA performance and interactions with specific TME cell populations will provide better strategies for cancer treatment and breast reconstruction after mastectomy.© 2024 The Authors.