本研究重点关注从 W. bifurcata 果皮提取物中提取的氧化锌纳米颗粒 (ZnONP) 的合成、表征和使用。 ZnONP 通常是利用既经济又环保的绿色技术合成的。利用分析技术对 ZnONP 进行了表征。紫外可见 (UV-Vis) 光谱显示峰值位于 364 nm，证实了 ZnONP 的产生。扫描电子显微镜分析表明，生成的纳米颗粒呈球形/团聚，直径范围为 11 至 25 nm。 FTIR 光谱用于识别负责纳米粒子还原、稳定和封端的特定官能团。提取物的植物化学分析表明存在类黄酮、皂苷、类固醇、三萜类化合物和树脂。评估了 W. bifurcata 合成纳米颗粒对病原菌的抗菌活性。使用 DPPH 测定评估 ZnONPs 抗氧化活性。针对前列腺癌 PC3 细胞评估了体外细胞毒性。通过在 Wistar 大鼠中采用体外划痕试验和体内切除模型来评估伤口愈合潜力。由于其生产环境友好、低毒和生物相容性，ZnONPs表现出潜在的抗菌、抗氧化、抗癌和伤口愈合活性，表明它们可用于癌症治疗和伤口处理。需要进一步研究以检查基本机制并评估测试样本在临床情况下的安全性和有效性。版权所有 © 2024 Moalwi、Kamat、Muddapur、Aldoah、AlWadai、Alamri、Alrashid、Alsareii、Mahnashi、Shaikh、Khan 等。

This study focuses on the synthesis, characterization, and use of zinc oxide nanoparticles (ZnONPs) derived from W. bifurcata fruit peel extract. ZnONPs are frequently synthesized utilizing a green technique that is both cost-effective and ecologically friendly. ZnONPs were characterized utilizing analytical techniques. Ultra Violet visible (UV-Vis) spectra showed peaks at 364 nm, confirming the production of ZnONPs. Scanning Electron Microscope analysis indicated that the nanoparticles generated were spherical/agglomerated, with diameters ranging from 11 to 25 nm. FTIR spectroscopy was used to identify the particular functional groups responsible for the nanoparticles' reduction, stabilization, and capping. Phytochemical analysis of the extract revealed that flavonoids, saponins, steroids, triterpenoids, and resins were present. The antibacterial activity of W. bifurcata synthesised nanoparticles was evaluated against pathogenic bacteria. The ZnONPs antioxidant activity was assessed using DPPH assay. The in vitro cytotoxicity was assessed against prostate cancer PC3 cells. The wound healing potential was assessed by employing in vitro scratch assay and in vivo excision model in Wistar rats. Because of its environmentally benign production, low toxicity, and biocompatibility, ZnONPs exhibited potential antibacterial, antioxidant, anticancer, and wound healing activities, indicating that they could be used in cancer treatment and wound management. Further study is required to examine the fundamental mechanisms and evaluate the safety and effectiveness of the test sample in clinical situations.Copyright © 2024 Moalwi, Kamat, Muddapur, Aldoah, AlWadai, Alamri, Alrashid, Alsareii, Mahnashi, Shaikh, Khan and More.