近年来，天然产物以其多成分、多靶点、安全性好的优点逐渐成为新药研发的重要来源。补骨脂素是从中药补骨脂中提取的呋喃香豆素类化合物，广泛分布于多种植物中。由于其药理活性，包括抗肿瘤、抗炎、抗氧化和神经保护作用，它引起了研究界的广泛关注。研究表明，补骨脂素具有广谱抗肿瘤活性，可抵抗乳腺癌、肝癌、神经胶质瘤、骨肉瘤等恶性肿瘤，使其成为一种天然的新型潜在抗肿瘤药物。补骨脂素主要通过抑制肿瘤细胞增殖、诱导细胞凋亡、抑制肿瘤细胞迁移、逆转多药耐药等发挥抗肿瘤作用，在抗肿瘤治疗领域具有广阔的应用前景。随着补骨脂研究的深入，其安全性受到关注，关于补骨脂素肝毒性的报道也逐渐增多。因此，本文对近年来补骨脂素抗肿瘤作用机制的研究进行综述，重点探讨其肝毒性的分子机制，为低毒、高效抗肿瘤药物的临床开发和临床用药的安全性提供参考。版权所有© 2024年孟、董、商、孙。

In recent years, natural products have gradually become an important source for new drug development due to their advantages of multi-components, multi-targets, and good safety profiles. Psoralen, a furanocoumarin compound extracted from the traditional Chinese medicine psoralea corylifolia, is widely distributed among various plants. It has attracted widespread attention in the research community due to its pharmacological activities, including antitumor, anti-inflammatory, antioxidant, and neuroprotective effects. Studies have shown that psoralen has broad spectrum anti-tumor activities, offering resistance to malignant tumors such as breast cancer, liver cancer, glioma, and osteosarcoma, making it a natural, novel potential antitumor drug. Psoralen mainly exerts its antitumor effects by inhibiting tumor cell proliferation, inducing apoptosis, inhibiting tumor cell migration, and reversing multidrug resistance, presenting a wide application prospect in the field of antitumor therapy. With the deepening research on psoralea corylifolia, its safety has attracted attention, and reports on the hepatotoxicity of psoralen have gradually increased. Therefore, this article reviews recent studies on the mechanism of antitumor effects of psoralen and focuses on the molecular mechanisms of its hepatotoxicity, providing insights for the clinical development of low-toxicity, high-efficiency antitumor drugs and the safety of clinical medication.Copyright © 2024 Meng, Dong, Shang and Sun.