多酚化合物是各种治疗应用中研究最广泛的化合物之一。然而，在此类化合物中，对天然存在的苯乙醇苷的研究最少。其中一种苯乙醇苷，毛蕊花苷 (Vb)，广泛存在于 23 个科 200 种植物中，由于其广谱治疗特性，如抗氧化、抗菌、抗炎、神经保护、心脏保护、皮肤保护等，最近受到关注。抗癌。尽管具有多种治疗功效，但由于其尺寸较大，该化合物的口服和局部应用的生物利用度较差。为了满足这些限制，目前对 Vb 的研究重点是通过纳米制剂来提供它。目前，大多数开发的制剂都是基于脂质体的，用于各种应用，例如角膜上皮伤口愈合、抗神经病变、抗皱、抗痛觉过敏、特应性皮炎、脱发和皮肤伤口愈合。多项研究已证实 Vb 的急性和亚急性毒性最小。关于 Vb 用于治疗 COVID-19、肾病、血小板聚集、慢性原发性肾小球肾炎和急性肝炎的临床研究很少。最近的研究表明，维生素B在伤口愈合、皮炎、神经保护和抗癌活性方面具有巨大的治疗潜力，这就需要为其各自的用途开发新的制剂。应强调长期毒性研究和通过生物技术方法扩大 Vb 生产的技术。© 2024。作者获得 Springer Nature Switzerland AG 的独家许可。

Polyphenolic compounds are among the most widely researched compounds for various therapeutic applications. However, naturally occurring phenylethanoid glycosides are least explored under this class of compounds. One such phenylethanoid glycoside, verbascoside (Vb), abundantly found among 200 species of 23 families, has gained recent attention due to its wide-spectrum therapeutic properties such as antioxidant, antimicrobial, anti-inflammatory, neuroprotective, cardioprotective, skin-protective, and anti-cancer. Despite having multiple therapeutic benefits, due to its large size, the compound has poor bioavailability for oral and topical applications. To meet these limitations, current research on Vb focuses on delivering it through nanoformulations. Presently, most developed formulations are liposome based for various applications, such as corneal epithelial wound healing, anti-neuropathic, anti-wrinkle, anti-hyperalgesia, atopic dermatitis, alopecia, and cutaneous wound healing. Multiple studies have confirmed the least acute and sub-acute toxicity for Vb. Few clinical studies have been performed for the therapeutic application of Vb to manage COVID-19, nephropathy, platelet aggregation, chronic primary glomerulonephritis, and acute hepatitis. Recent studies have shown the immense therapeutic potential of Vb in wound healing, dermatitis, neuroprotection, and anti-cancer activities, which creates a need for developing novel formulations for their respective uses. Long-term toxicity studies and techniques for scaling up Vb production by biotechnological approaches should be emphasized.© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.