Yellapragada SubbaRow 博士是一位出生于印度的美国生物化学家，在各个科学领域取得了众多发现。 1895 年，他出生于一个贫困家庭，随后在印度泰米尔纳德邦钦奈的马德拉斯医学院接受医学培训。历经千辛万苦，他抵达美国，并获得哈佛大学热带医学文凭和生物化学博士学位。他辉煌的职业生涯始于与菲斯克一起分离体液中的磷。他们还发现了磷酸肌酸和三磷酸腺苷（ATP）。后来他成为 Lederle 实验室的主任，在那里他发现了四环素抗生素组，拯救了许多人的生命。他合成了许多维生素，包括叶酸、烟酸和生物素。 1948 年，他发现了治疗儿童癌症的甲氨蝶呤 (MTX)，这为许多化疗药物铺平了道路，并且还用于治疗多种自身免疫性疾病。尽管 SubbaRow 取得了许多医学进步，但科学界对他的一生和许多贡献的认识仍未得到充分认识。本文简要讨论了 SubbaRow 的生活、学术和成就。© 印度医师协会杂志 2024 年。

Dr Yellapragada SubbaRow was an Indian-born American biochemist who made numerous discoveries in various fields of science. Born in 1895 into a poor family, he went on to have medical training at the Madras Medical College, Chennai, Tamil Nadu, India. After many hardships, he arrived in the United States of America and earned a diploma in tropical medicine and a PhD in biochemistry from Harvard. His illustrious career began with the isolation of phosphorus in body fluids along with Fiske. They discovered phosphocreatine and adenosine triphosphate (ATP) as well. He later became the director of Lederle Laboratories, where he discovered the tetracycline antibiotic group, which saved many lives. He synthesized many vitamins, including folic acid, niacin, and biotin. In 1948, he discovered methotrexate (MTX) for childhood cancer, which paved the way for many chemotherapeutics and is also used in the management of several autoimmune conditions. Despite numerous medical advancements made by SubbaRow, awareness in the scientific world regarding his life and many contributions remains underrecognized. This article discusses SubbaRow's life, academics, and achievements in a nutshell.© Journal of the Association of Physicians of India 2024.