化疗作为常用的抗癌治疗方式，常常受到化疗药物稳定性差、溶解度低、副作用严重以及癌细胞的多药耐药等多种障碍的挑战。纳米颗粒作为化疗药物的载体和结合不同治疗方法的平台有效地参与了克服这些缺点。特别是，纳米粒子能够响应肿瘤微环境特征（例如缺氧、酸性pH、高水平的谷胱甘肽和过表达的过氧化氢）或激光的外在刺激等特定刺激而诱导治疗效果，从而带来更精确和选择性的治疗。其中，共价有机框架（COF）纳米结构近年来引起了生物医学领域的极大兴趣。这些生物相容性多孔结晶聚合物具有大表面积、高孔隙率、结构稳定性和可定制的架构，可以适当地转化为有前途的药物输送和联合治疗诱导平台。本研究重点关注纳米级 COF 的刺激响应特性，旨在概述其在单独化疗或与声动力、化学动力、光动力和光热疗法相结合的癌症治疗中的潜力。

Chemotherapy as a common anticancer therapeutic modality is often challenged by various obstacles such as poor stability, low solubility, and severe side effects of chemotherapeutic agents as well as multidrug resistance of cancerous cells. Nanoparticles in the role of carriers for chemotherapeutic drugs and platforms for combining different therapeutic approaches have effectively participated in overcoming such drawbacks. In particular, nanoparticles able to induce their therapeutic effect in response to specific stimuli like tumor microenvironment characteristics (e.g., hypoxia, acidic pH, high levels of glutathione, and overexpressed hydrogen peroxide) or extrinsic stimulus of laser light bring about more precise and selective treatments. Among them, nanostructures of covalent organic frameworks (COFs) have drawn great interest in biomedical fields during recent years. Possessing large surface area, high porosity, structural stability, and customizable architecture, these biocompatible porous crystalline polymers properly translate to promising platforms for drug delivery and induction of combination therapies. With the focus on stimuli-responsive characteristics of nanoscale COFs, this study aims to propose an overview of their potentiality in cancer treatment on the basis of chemotherapy alone or in combination with sonodynamic, chemodynamic, photodynamic, and photothermal therapies.