自驱动纳米马达具有强大的推进和穿透能力，可以提高纳米粒子的细胞摄取效率，增强其对肿瘤细胞的细胞毒性，为治疗重大疾病开辟新途径。在这项研究中，提出了通过交替拉伸和收缩温度敏感聚合物（TS-P）链来驱动纳米电机的概念。 TS-Ps 成功连接到 Cu2-xSe@Au (CS@Au) 纳米粒子的一侧，形成 Janus 结构，该结构被指定为 Cu2-xSe@Au 聚合物 (CS@Au-P) 纳米电机。在近红外（NIR）光照射下，Cu2-xSe纳米粒子产生光热效应，改变系统温度，触发TS-P结构的交替，产生机械力，推动CS@Au-P纳米电机运动。纳米马达显着提高了纳米颗粒的细胞摄取并增强了它们在肿瘤中的渗透和积累。此外，CS@Au-P纳米电机卓越的光热转换效率表明它们作为光热疗法（PTT）纳米材料的潜力。所制备的材料在体内和体外均表现出良好的生物相容性和抗肿瘤作用，为纳米电机在肿瘤治疗中的设计和应用提供了新的研究见解。© 2024 Wiley‐VCH GmbH。

Self-propelled nanomotors possess strong propulsion and penetration abilities, which can increase the efficiency of cellular uptake of nanoparticles and enhance their cytotoxicity against tumor cells, opening a new path for treating major diseases. In this study, the concept of driving nanomotors by alternately stretching and contracting a temperature-sensitive polymer (TS-P) chain is proposed. The TS-Ps are successfully linked to one side of Cu2-xSe@Au (CS@Au) nanoparticles to form a Janus structure, which is designated as Cu2-xSe@Au-polymer (CS@Au-P) nanomotors. Under near-infrared (NIR) light irradiation, Cu2-xSe nanoparticles generate photothermal effects that change the system temperature, triggering the alternation of the TS-P structure to generate a mechanical force that propels the motion of CS@Au-P nanomotors. The nanomotor significantly improved the cellular uptake of nanoparticles and enhanced their penetration and accumulation in tumor. Furthermore, the exceptional photothermal conversion efficiency of CS@Au-P nanomotors suggests their potential as nanomaterials for photothermal therapy (PTT). The prepared material exhibited good biocompatibility and anti-tumor effects both in vivo and in vitro, providing new research insights into the design and application of nanomotors in tumor therapy.© 2024 Wiley‐VCH GmbH.