非传染性疾病 (NCD) 构成重大的全球健康挑战，占死亡率和发病率的 80% 以上。这一负担在包括埃塞俄比亚在内的低收入和中等收入国家（LMIC）尤其明显。尽管如此，非洲对此问题的研究仍然有限。本研究旨在调查埃塞俄比亚三所三级医院住院人群中非传染性疾病的患病率、模式和结果。一项以医院为基础的队列研究（2022 年 8 月至 2023 年 1 月）包括 14 岁及以上被诊断患有心血管疾病 (CVD) 的患者、糖尿病 (DM)、慢性阻塞性肺病 (COPD)、哮喘或癌症在埃塞俄比亚三家医院进行。通过医疗记录和访谈收集有关人口统计、社会经济因素、临床特征和结果的数据。 Logistic 回归确定了与院内死亡率独立相关的因素，p≤≤0.05 被认为具有统计显着性。在涉及三家三级医院、涉及 2,237 名患者的研究中，我们发现了非传染性疾病的影响。约23.4%的患者患有非传染性疾病，其中心血管疾病（53.3%）、癌症（29.6%）、糖尿病（6.1%）和呼吸系统疾病（6.5%）最为常见。值得注意的是，在受影响的患者中，女性略占多数（55.1%），患者平均年龄为 47.2 岁。不幸的是，15.3% 的非传染性疾病患者面临院内死亡。我们的分析揭示了死亡率的预测因素，包括癌症诊断（调整后比值比 [AOR]：1.6，95% CI：1.2-1.8，p = 0.01）、药物依从性（AOR：0.36，95% CI：0.21-0.64，p < 0.001）、并发感染（AOR：0.36，95% CI：0.16-0.86，p < 0.001）、慢性肾脏病（CKD）（AOR：0.35，95% CI：0.14-0.85，p = 0.02）以及治疗期间的并发症住院（AOR：6.36，95% CI：3.45-11.71，p<0.001）。我们的研究显示住院患者中非传染性疾病的患病率很高，影响大约四分之一的人，主要患有心血管疾病和癌症。令人担忧的是，这些患者中有很大一部分未能在住院期间存活下来，这强调了迫切需要有针对性的干预措施来改善该人群的预后。© 2024。作者。

Non-communicable diseases (NCDs) pose a significant global health challenge, constituting over 80% of mortality and morbidity. This burden is particularly pronounced in low- and middle-income countries (LMICs), including Ethiopia. Despite this, there's limited research on this issue in Africa. This study aims to investigate the prevalence, patterns, and outcomes of NCDs in hospitalized populations across three tertiary hospitals in Ethiopia.A hospital-based cohort study (August 2022 - January 2023) included patients aged 14 and older diagnosed with cardiovascular diseases (CVDs), diabetes mellitus (DM), chronic obstructive pulmonary disease (COPD), asthma, or cancer at three Ethiopian hospitals. Data on demographics, socio-economic factors, clinical characteristics, and outcomes were collected through medical records and interviews. Logistic regression identified factors independently associated with in-hospital mortality, with p ≤ 0.05 considered statistically significant.In the study across three tertiary hospitals involving 2,237 patients, we uncovered the impact of NCDs. About 23.4% of patients struggled with NCDs, with cardiovascular diseases (53.3%), cancer (29.6%), diabetes (6.1%), and respiratory diseases (6.5%) being the most prevalent. Notably, among those affected, women comprised a slight majority (55.1%), with the average patient age being 47.2 years. Unfortunately, 15.3% of patients with NCDs faced in-hospital mortality. Our analysis revealed predictors of mortality, including cancer diagnosis (adjusted odds ratio [AOR]:1.6, 95% CI: 1.2-1.8, p = 0.01), medication adherence ( AOR: 0.36, 95% CI: 0.21-0.64, p < 0.001), concurrent infections (AOR: 0.36, 95% CI: 0.16-0.86, p < 0.001), chronic kidney diseases (CKD) (AOR: 0.35, 95% CI: 0.14-0.85, p = 0.02), and complications during hospitalization (AOR: 6.36, 95% CI: 3.45-11.71, p < 0.001).Our study reveals a substantial prevalence of NCDs among hospitalized patients, affecting approximately one in four individuals, primarily with CVDs and cancer. Alarmingly, a significant proportion of these patients did not survive their hospitalization, emphasizing the urgent need for targeted interventions to enhance outcomes in this population.© 2024. The Author(s).