据报道，氧化还原失衡在肿瘤发生、癌症发展和耐药性中发挥着关键作用。严重的氧化损伤是癌细胞对治疗反应的一般结果，可能导致癌细胞死亡或严重的副作用。为了维持寿命，癌细胞可以挽救氧化还原平衡并进入对抗癌药物的抵抗状态。因此，针对氧化还原信号通路已成为增强抗癌药物疗效并减少其不良反应的一种有吸引力且具有前瞻性的策略。在过去的几十年里，天然产物（NPs）因其高效低毒而成为开发新抗癌药物的宝贵来源。越来越多的证据表明，许多纳米颗粒无论单独使用还是作为佐剂都表现出显着的抗肿瘤作用，并且正在成为通过调节氧化还原平衡来增强敏感性并减少传统癌症治疗的副作用的有效方法。其中有数种基于纳米粒子的新型抗癌药物已进入临床试验。在这篇综述中，我们总结了纳米粒子与常规抗癌药物联合的协同抗癌作用和相关的氧化还原机制。我们相信，针对氧化还原调节的纳米颗粒将代表有前途的新型候选药物，并为未来的癌症治疗提供前景。© 2024。作者。

Redox imbalance is reported to play a pivotal role in tumorigenesis, cancer development, and drug resistance. Severe oxidative damage is a general consequence of cancer cell responses to treatment and may cause cancer cell death or severe adverse effects. To maintain their longevity, cancer cells can rescue redox balance and enter a state of resistance to anticancer drugs. Therefore, targeting redox signalling pathways has emerged as an attractive and prospective strategy for enhancing the efficacy of anticancer drugs and decreasing their adverse effects. Over the past few decades, natural products (NPs) have become an invaluable source for developing new anticancer drugs due to their high efficacy and low toxicity. Increasing evidence has demonstrated that many NPs exhibit remarkable antitumour effects, whether used alone or as adjuvants, and are emerging as effective approaches to enhance sensitivity and decrease the adverse effects of conventional cancer therapies by regulating redox balance. Among them are several novel anticancer drugs based on NPs that have entered clinical trials. In this review, we summarize the synergistic anticancer effects and related redox mechanisms of the combination of NPs with conventional anticancer drugs. We believe that NPs targeting redox regulation will represent promising novel candidates and provide prospects for cancer treatment in the future.© 2024. The Author(s).