肾小球肾炎 (GN) 是肾脏炎症的一个重要原因，该炎症是由肾脏靶向的适应性和先天免疫反应以及随后的肾小球损伤引起的。鉴于某些形式的肾小球肾炎缺乏自身抗体、免疫复合物或浸润性免疫细胞，例如局灶性节段性肾小球硬化症和微小病变性疾病，以及副肿瘤综合征和某些病毒感染中肾脏受累的特殊形式，最可能的病因是情况是分泌因子，主要是细胞因子。由于细胞因子可以调节 GN 的炎症机制、严重程度和临床结果，因此将细胞因子 GN 的总称视为对一组先前已知的 GN 进行重新分类的新观点是合理的。我们在此特别关注在 GN 发展中具有核心“规范效应”的细胞因子。© 2024 Wiley periodicals LLC。

Glomerulonephritis (GN) is an important cause of renal inflammation resulting from kidney-targeted adaptive and innate immune responses and consequent glomerular damage. Given the lack of autoantibodies, immune complexes, or the infiltrating immune cells in some forms of GN, for example, focal segmental glomerulosclerosis and minimal change disease, along with paraneoplastic syndrome and a special form of renal involvement in some viral infections, the likeliest causative scenario would be secreted factors, mainly cytokine(s). Since cytokines can modulate the inflammatory mechanisms, severity, and clinical outcomes of GN, it is rational to consider the umbrella term of cytokine GN as a new outlook to reclassify a group of previously known GN. We focus here, particularly, on cytokines that have the central "canonical effect" in the development of GN.© 2024 Wiley Periodicals LLC.