高剂量化疗联合自体造血细胞移植（AutoHCT）长期以来一直是多发性骨髓瘤和非霍奇金淋巴瘤的综合治疗方式。在过去的 25 年里，许多机构已将这一做法从需要住院转为可以在门诊环境中进行，从而节省了成本并提高了患者的生活质量。最近出现的免疫效应细胞（IEC）疗法及其适应症的扩展正在改变血液和非血液恶性肿瘤的治疗格局。然而，如果这种治疗方式继续需要住院管理，当前的财务模式和报销结构就会威胁到这种治疗方式的可行性和可持续性。这种威胁促使机构根据门诊 AutoHCT 模板开发门诊 IEC 计划。两者的成功不可或缺的是一个有凝聚力的计划，其中包括门诊特定的标准操作方案、训练有素的提供者和在这些治疗方式方面具有专业知识的工作人员、循证的支持性护理和预防计划、广泛的护理人员审查和教育以及基础设施支持所有相关个人。在本政策和实践审查中，我们概述了指南和已发表的学术经验，对我们机构中参与此过程的个人的角色和责任进行了基于视角的描述，并强调了可以传播的可行建议以及更广泛地实施门诊 AutoHCT 和 IEC 计划。版权所有 © 2024 Goldsmith、San-Rozano、Katindoy、Rattanapichetkul 和 Rosenzweig。

High-dose chemotherapy with autologous hematopoietic cell transplantation (AutoHCT) has long been an integral treatment modality for multiple myeloma and non-Hodgkin lymphoma. Over the past 25 years, numerous institutions have shifted this practice from requiring hospitalization to one that can be performed in an ambulatory setting, resulting in cost savings and improved quality of life for patients. The recent advent immune-effector cell (IEC) therapies and expansion of their indications is changing the treatment landscape for hematologic and non-hematologic malignancies. However, current financial models and reimbursement structures threaten the viability and sustainability of this treatment modality should it continue to require inpatient administration and management. This threat is leading institutions to develop outpatient IEC programs based off the outpatient AutoHCT templates. Integral to the success of both is a cohesive program with outpatient-specific standard operating protocols, highly-trained providers and staff with expertise specific in these treatment modalities, evidenced-based supportive care and prophylaxis plans, extensive caregiver vetting and education, and the infrastructure to support all individuals involved. In this policy and practice review we provide an overview of the guidelines and published academic experiences, give a perspective-based description of the roles and responsibilities of the individuals involved in this process at our institution, and highlight actionable recommendations that could allow for the dissemination and implementation of outpatient AutoHCT and IEC programs more broadly.Copyright © 2024 Goldsmith, San-Rozano, Katindoy, Rattanapichetkul and Rosenzweig.