生育问题是接受乳腺癌 (BC) 治疗的年轻女性非常关心的问题。使用来曲唑控制性卵巢刺激（COS）的生育力保存（FP）方案已得到广泛应用，总体效果良好。然而，在这种情况下，来曲唑不能在每个国家都使用。本研究旨在评估他莫昔芬对接受 FP 的早期 BC 女性 COS 的疗效。这项多中心前瞻性研究包括年龄 18-40 岁、诊断为 I、II 和 III 期侵袭性 BC、在辅助或新辅助化疗前接受他莫昔芬-COS 的患者（NAC）。主要终点是通过收集和玻璃化冷冻的卵母细胞数量评估他莫昔芬-COS方案的功效。次要终点包括化疗前的时间间隔、乳腺癌 (BC) 复发率和生殖结局。2014 年至 2017 年期间纳入了 95 名患者，平均年龄为 31.5 ± 4 岁。 37.9% 接受 NAC，62.1% 接受辅助化疗。 FP 程序在 89.5% 的周期中成功。收集和玻璃化冷冻卵母细胞的平均数量分别为 12.8 ± 7.9 和 9.8 ± 6.2。 COS 的平均持续时间为 10.4 ± 1.9 天。接受 NAC 的女性开始化疗前的中位时间为 3.6 周（IQR 3.1；4.1）。五年无复发率和总生存率与该人群的预期一致。 21 名女性自发足月妊娠，5 名女性接受了冻融卵母细胞的 IVF 周期，但没有怀孕。在年轻 BC 患者中，在辅助或 NAC 治疗之前，他莫昔芬-COS 方案似乎是可行的，并且在卵母细胞产量方面是有效的。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Fertility issues are of great concern for young women undergoing treatment for breast cancer (BC). Fertility preservation (FP) protocols using controlled ovarian stimulation (COS) with letrozole have been widely used with overall good results. However, letrozole cannot be used in every country in this context. This study aimed to assess the efficacy of tamoxifen for COS in women with early BC undergoing FP.This multicentric prospective study included patients aged 18-40, diagnosed with stage I, II and III invasive BC, undergoing tamoxifen-COS before adjuvant or neoadjuvant chemotherapy (NAC). The primary endpoint was the efficacy of tamoxifen-COS protocol evaluated by the number of oocytes collected and vitrified. Secondary endpoints included the time interval before chemotherapy, breast cancer (BC) recurrence rates, and reproductive outcomes.Ninety-five patients were included between 2014 and 2017, aged 31.5 ± 4 years on average. 37.9 % received NAC and 62.1 % received adjuvant chemotherapy. FP procedure was successful in 89.5 % of the cycles. The mean number of collected and vitrified oocytes was 12.8 ± 7.9 and 9.8 ± 6.2, respectively. The mean duration of COS was 10.4 ± 1.9 days. Median time before chemotherapy initiation was 3.6 weeks (IQR 3.1; 4.1) for women receiving NAC. Five-year relapse-free and overall survival rates were in-line with those expected in this population. Twenty-one women had spontaneous full-term pregnancies, while 5 underwent IVF cycles with frozen-thawed oocytes, without pregnancy.Tamoxifen-COS protocols appear to be feasible before adjuvant or NAC treatment in young BC patients and efficient in terms of oocyte yield.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.