旨在调查淋巴结（LN）产量是否影响甲状腺乳头状癌（PTC）颈后淋巴结转移（N1b）儿科患者的临床结果。这项队列研究于2008年1月1日至2022年12月31日进行， 2008-2021年在中国西南地区3家医院接受全甲状腺切除术和治疗性淋巴结清扫术的N1b PTC儿童患者（年龄≤18岁），随访至2022年。排除远处转移患者。使用单变量和多变量 Cox 比例风险回归分析来确定与持续性/复发性疾病相关的因素。总共分析了 102 名儿科患者（中位年龄 [范围]，16 [6-18] 岁）：36 名患者 (35%)与T1； 27 名患者 (26%)，T2； 18 名患者 (18%)，T3； 21 名患者 (21%)，T4。在中位随访 50 个月（范围 12-154 个月）期间，40 名 (39%) 患者出现持续性疾病。受试者操作特征分析确定了 LN 产量截止值（<42 LN）以预测持续性疾病。多变量分析显示，较小范围的淋巴结切除术（<42 个淋巴结）是持续性疾病的独立危险因素（风险比，2.4；95% 置信区间，1.09-5.29；P=.029）。我们的研究强调，较高的淋巴结切除术产量可能会对 N1b PTC 儿科患者的预后产生有利影响。版权所有 © 2024 Elsevier Ltd。保留所有权利。

To investigate whether lymph node (LN) yield influences clinical outcomes for pediatric patients with laterocervical lymph node metastasis (N1b) from papillary thyroid cancer (PTC).Conducted from January 1, 2008, to December 31, 2022, this was a cohort study of pediatric patients (aged ≤ 18 years) with N1b PTC who underwent total thyroidectomy and therapeutic LN dissection in the central and lateral compartments at 3 hospitals in southwest China in 2008-2021, with follow-up until 2022. Patients with distant metastasis were excluded. Univariate and multivariate Cox proportional hazards regression analyses were used to identify factors associated with persistent/recurrent diseases.A total of 102 pediatric patients (median [range] age, 16 [6-18] years) were analyzed: 36 patients (35 %) with T1; 27 patients (26 %), T2; 18 patients (18 %), T3; and 21 patients (21 %), T4. During a median follow-up of 50 months (range, 12-154 months), persistent diseases occurred in 40 (39 %) patients. Receiver operating characteristic analysis identified LN yield cut-off (<42 LNs) to predict persistent diseases. Multivariate analysis revealed that a less-extensive lymphadenectomy (<42 LNs) was an independent risk factor for persistent diseases (hazard ratio, 2.4; 95 % confidence intervals, 1.09-5.29; P=.029).Our study highlights that a higher LN yield may favorably influence prognosis in pediatric patients with N1b PTC.Copyright © 2024 Elsevier Ltd. All rights reserved.