生物阻抗形式主义:一种获取细胞和组织健康状态的新方法。
Bioimpedance formalism: A new approach for accessing the health status of cell and tissues.
发表日期:2024 Aug 19
作者:
Jose Luis García Bello, Taira Batista Luna, Alcibíades Lara Lafargue, Héctor Manuel Camué Ciria, Yohandys A Zulueta
来源:
BIOELECTROCHEMISTRY
摘要:
该手稿描述了一种利用生物阻抗谱测量的特征频率来研究组织和细胞的弛豫动力学的新颖方法。生物阻抗形式允许同时研究频域和时域中的生物电参数,从而深入了解感兴趣的组织或细胞中可能发生的松弛过程。科尔-科尔分析的结果显示,不存在与异质性相关的多重松弛过程,与女性相比,男性的年龄组存在明显的分离。对时域弛豫动态的研究表明,β参数可用于分析组织、细胞或癌细胞中的电荷载体,可能为癌症和其他疾病带来新的诊断和治疗方法。总体而言,这种方法为利用生物阻抗方法深入了解组织和细胞的电特性提供了一个有前景的研究领域。版权所有 © 2024 Elsevier B.V. 保留所有权利。
This manuscript describes a novel methodology for studying relaxation dynamics in tissues and cells using characteristic frequency of bioimpedance spectroscopy measurements. The Bioimpedance Formalism allows for the simultaneous study of bioelectrical parameters in the frequency and time domains, providing insight into possible relaxation processes occurring in the tissue or cell of interest. Results from the Cole-Cole analysis showed no multiple relaxation processes associated with heterogeneity, with a visible age group separation in males compared with females. The study of the relaxation dynamic in the time domain revealed that the β parameter can be used to analyse the charge carriers in tissues, cells, or cancer cells, potentially leading to new diagnostic and therapeutic approaches for cancer and other diseases. Overall, this approach presents a promising area of research for gaining insights into the electrical properties of tissues and cells using bioimpedance methods.Copyright © 2024 Elsevier B.V. All rights reserved.