切口、烧伤和创伤等医学表现将引发自然的伤口愈合过程，其中涉及细胞之间复杂的相互作用。苏木中发现的巴西素和其他次生代谢物具有多种生物活性，包括抗炎、抗癌和抗氧化特性。本研究旨在研究苏木 (Caesalpinia Sappan L.) 乙醇提取物局部用于切口伤口的功效白化大鼠愈合。20只雄性大鼠随机分为5组，每组4次，即(C-)以软膏为主，(C)以10%聚维酮碘治疗，(T1、T2、T3组) ）分别用浓度为 6.5%、15% 和 30% 的苏木提取物进行处理。该治疗每天两次局部施用于受伤部位，持续 15 天。伤口愈合通过以下参数进行组织学评估：胶原沉积、多形核中性粒细胞（PMN）、血管生成和纤维化程度

Medical manifestations in the form of incisions, burns, and trauma will trigger a natural wound-healing process that involves complex interactions between cells. Brazilin and other secondary metabolites found in Sappan wood have numerous bioactive qualities, including anti-inflammatory, anti-cancer, and antioxidant properties.This study aimed to investigate the efficacy of Sappan wood (Caesalpinia Sappan L.) ethanol extract topically on the incision wound healing of albino rats.Twenty male rats were randomly assigned into five groups with four replications, i.e., (C-) was treated ointment-based, (C+) was treated with 10% povidone-iodine, (T1, T2, and T3 groups) were treated with Sappan wood extract concentration for 6.5%, 15%, and 30%, respectively. The treatment was topically administered to wounded areas twice a day for 15 days. Wound healing was evaluated histologically as the following parameters collagen deposition, polymorphonuclear neutrophils (PMN), angiogenesis, and fibrosis degree using H&E staining. IL-2 level was evaluated using the enzyme-linked immunosorbent assay (ELISA) method. Wound length reduction was calculated on days 8 and 15.As a result, the 6.5% (T1), 15% (T2), and 30% (T3) Sappan wood extract groups were improved significantly (p < 0.05) compared to ointment-based (C-) and povidone-iodine (C+) groups on the collagen deposition, PMN, angiogenesis, fibrosis degree, and IL-2 level. In particular, the 6.5% (T1) Sappan wood extract group was highlighted significantly (p < 0.05) compared to other groups, evidenced by the improvisation of wound healing parameters and reduction of wound length on days 8 and 15.In conclusion, a 6.5% Sappan wood extract revealed its applicability to improve incision wound healing in albino rats.