非霍奇金淋巴瘤 (NHL) 是最常见的胃肠道 (GI) 淋巴瘤类型，具有出血、梗阻和穿孔等已知并发症。在本文中，我们介绍了一名 59 岁男性患者，该患者被诊断患有外周 T 细胞淋巴瘤 - 未明确说明 (PTCL-NOS)，并开始接受化疗，并伴有胃肠道受累。第一个周期化疗完成后第 2 天，患者因突然出现腹痛和腹胀而被送往急诊室。经过评估，他被诊断出小肠多处穿孔。患者接受了初步修复少数穿孔的探查和双筒回肠造口术的回肠切除术。化疗在 NHL 的治疗中发挥着重要作用。一种众所周知的 NHL 后果是肠穿孔，可能发生在初次就诊时或开始化疗后。外科医生应该意识到此类并发症的可能性和穿孔的高危因素。目前，择期手术在胃肠道淋巴瘤中尚无作用，主要用于治疗出血不受控制、梗阻或穿孔等并发症。

Non-Hodgkin's lymphoma (NHL) is the most common type of Gastrointestinal (GI) lymphoma with known complications such as bleeding, obstruction and perforation. In this article we present a 59-year-old male patient diagnosed with Peripheral T cell Lymphoma - Not Otherwise Specified (PTCL-NOS) with GI involvement was started on chemotherapy. On day 2 post completion of first cycle of chemotherapy, patient had presented to the emergency department with sudden onset abdominal pain and distension. On evaluation, he was diagnosed with multiple perforations in the small bowel. Patient underwent exploration with primary repair of few perforations and ileal resection with double barrel ileostomy. Chemotherapy plays an important role in the management of NHL. One well-known NHL consequence, intestinal perforation, can happen at the time of initial presentation or after starting chemotherapy. Surgeons should be aware of possibility of such complications and high-risk factors for perforation. At present, there is no role for elective surgery in GI lymphoma and is mainly reserved for complications like uncontrolled bleeding, obstruction or perforation.