癫痫持续状态 (SE) 在院内死亡率和费用方面造成了巨大负担，但 SE 原因、患者合并症、死亡率和费用之间的关系仍不清楚。我们使用大型综合数据库确定了 SE 的院内死亡率和成本驱动因素。我们进行了一项回顾性队列研究，涉及自 2015 年 1 月 1 日起首次住院且 ICD-10 代码诊断为 SE 的患者。截至2019年12月31日，使用覆盖99%人口的法国健康保险数据库。提取每次住院的患者特征、SE 原因、重症监护病房 (ICU) 入院情况、机械通气、出院状况和健康保险费用。我们确定了 52,487 名因首次 SE 住院的患者。 11,464 名患者发生院内死亡 (21.8%)，相关因素包括年龄（比值比 [OR]，10.3，95% 置信区间 [CI] 7.87-13.8，80 岁以上患者与 10-19 岁患者相比）、急性原因（缺氧原因的 OR，15.3，95% CI 13.9-16.8）、肿瘤（OR，1.75，95% CI 1.63-1.8）、合并症（与 0 相比，3 种或更多合并症的 OR，3.00，95% CI 2.79-3.24） ）和延长机械通气（OR，2.61，95% CI 2.42-2.82）。每次 SE 住院的报销费用中位数为 6517 欧元（3364-13,354），费用因素反映了院内死亡率。原因和合并症是癫痫持续状态死亡率和住院费用的主要决定因素，以及与癫痫持续状态较高相关的因素。死亡率往往还与较高的成本相关。需要进一步研究以确定其长期影响。© 2024。Springer-Verlag GmbH 德国，施普林格自然的一部分。

Status epilepticus (SE) imposes a significant burden in terms of in-hospital mortality and costs, but the relationship between SE causes, patient comorbidities, mortality, and cost remains insufficiently understood. We determined the in-hospital mortality and cost-driving factors of SE using a large and comprehensive database.We conducted a retrospective cohort study involving patients experiencing their first hospitalization with an ICD-10 code diagnosis of SE, spanning from January 1, 2015, to December 31, 2019, using the French health insurance database which covers 99% of population. Patient characteristics, SE causes, Intensive Care Unit (ICU) admissions, mechanical ventilation, discharge status, and health insurance costs were extracted for each hospitalization.We identified 52,487 patients hospitalized for a first SE. In-hospital mortality occurred in 11,464 patients (21.8%), with associated factors including age (Odds Ratio [OR], 10.3, 95% Confidence Interval [CI] 7.87-13.8 for ages over 80 compared to 10-19), acute causes (OR, 15.3, 95% CI 13.9-16.8 for hypoxic cause), tumors (OR, 1.75, 95% CI 1.63-1.8), comorbidities (OR, 3.00, 95% CI 2.79-3.24 for 3 or more comorbidities compared to 0), and prolonged mechanical ventilation (OR, 2.61, 95% CI 2.42-2.82). The median reimbursed cost for each SE hospitalization was 6517€ (3364-13,354), with cost factors mirroring those of in-hospital mortality.Causes and co-morbidities are major determinants of mortality and hospital costs in status epilepticus, and factors associated with higher mortality are also often associated with higher costs. Further studies are needed to identify their long-term effects.© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.