研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

C 反应蛋白-白蛋白-淋巴细胞 (CALLY) 指数是阻塞性结直肠癌结肠支架患者术后并发症的有用预测指标:一项日本多中心研究。

The C-reactive protein-albumin-lymphocyte (CALLY) index is a useful predictor of postoperative complications in patients with a colonic stent for obstructive colorectal cancer: a Japanese multicenter study.

发表日期:2024 Aug 23
作者: Toshio Shiraishi, Takashi Nonaka, Tetsuro Tominaga, Yuma Takamura, Kaido Oishi, Shintaro Hashimoto, Keisuke Noda, Rika Ono, Makoto Hisanaga, Hiroaki Takeshita, Mitsutoshi Ishii, Shosaburo Oyama, Kazuhide Ishimaru, Masaki Kunizaki, Terumitsu Sawai, Keitaro Matsumoto
来源: Immunity & Ageing

摘要:

C反应蛋白-白蛋白-淋巴细胞(CALLY)指数是一种新颖的评分标准,可以很好地反映营养状况、炎症反应和免疫系统状态。据报道,CALLY 指数与各种癌症的预后相关。本研究的目的是探讨 CA​​LLY 指数与结肠支架治疗的梗阻性结直肠癌短期预后之间的关系。 这项回顾性研究的对象是 263 名因梗阻性结直肠癌接受结肠支架置入术后接受结直肠切除术的患者。 2016 年至 2023 年间患癌症的患者被分为低 CALLY 指数组(CALLY-L 组,n = 85)和高 CALLY 指数组(CALLY-H 组,n = 178)。组失血量较多(53 mL vs 20 mL,p = 0.002),体能状态较差(PS3;20% vs 10.1%,p = 0.033)、开放手术(21.2% vs 7.3%,p = 0.001)、距离较远转移率(41.2% vs. 20.8%,p = 0.01)和术后并发症(30.6% vs. 18.5%,p = 0.039)均高于 CALLY-H 组。多变量分析发现手术时间延长(比值比 1.983,95% 置信区间 1.013-3.881;p = 0.045)、失血量较多(比值比 2.572,95% 置信区间 1.291-5.129;p = 0.007)和较低的 CALLY 指数(比值比 1.961,95% 置信区间 1.013-3.795;p = 0.045)作为并发症的独立预测因子。CALLY 指数可能是阻塞性结直肠癌术后并发症的有用预测因子。© 2024。作者拥有独家许可施普林格自然新加坡私人有限公司
The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel score that offers a good reflection of nutritional status, inflammatory response, and immune system status. The CALLY index is reported to correlate with the prognosis of various carcinomas. The purpose of the present study was to investigate the association between the CALLY index and the short-term prognosis of obstructive colorectal cancer managed with a colonic stent.The subjects of this retrospective study were 263 patients who underwent colorectal resection after colonic stenting for obstructive colorectal cancer between 2016 and 2023. Patients were classified into a group with a low CALLY index (CALLY-L group, n = 85) and a group with a high (CALLY-H group, n = 178) CALLY index.The CALLY-L group had greater blood loss (53 mL vs 20 mL, p = 0.002) and higher poor performance status (PS3; 20% vs 10.1%, p = 0.033), open surgery (21.2% vs 7.3%, p = 0.001), distant metastases (41.2% vs 20.8%, p = 0.01), and postoperative complications (30.6% vs. 18.5%, p = 0.039) than the CALLY-H group. Multivariate analysis identified a prolonged operative time (odds ratio 1.983, 95% confidence interval 1.013-3.881; p = 0.045), greater blood loss (odds ratio 2.572, 95% confidence interval 1.291-5.129; p = 0.007) and a low CALLY index (odds ratio 1.961, 95% confidence interval 1.013-3.795; p = 0.045) as independent predictors of complications.The CALLY index may be a useful predictor of postoperative complications of obstructive colorectal cancer.© 2024. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.