乳香树脂 (FR) 首次被羧甲基化产生 CMFR - AuNP，并将该缀合物用于阿霉素药物负载。 FR的羧基、酚基和羟基官能团的羧甲基化已开发成羧甲基化乳香树脂（CMFR）。使用开发的 CMFR 作为稳定剂和还原剂合成了一种新型 CMFR-AuNPs。利用CMFR-AuNPs和CMFR-AuNPs@DOX研究了抗菌、抗氧化和体外抗癌活性。 CMFR-AuNPs 通过有效猝灭 DPPH 自由基而表现出抗氧化特性。 CMFR-AuNPs 和 DOX@CMFR-AuNPs 对肺炎克雷伯菌、金黄色葡萄球菌、枯草芽孢杆菌和大肠杆菌表现出强大的抗菌活性。在不同浓度的负载 Dox 的 CMFR-AuNP（CMFR-AuNPs Dox1、CMFR-AuNPs Dox 2、

For the first time, Frankincense resin (FR) has been carboxymethylated to produce CMFR - AuNPs and the conjugate was utilized for the Doxorubicin drug loading. The carboxymethylation of the carboxylic, phenolic, and hydroxyl functional groups of FR has been developed into carboxymethylated Frankincense resin (CMFR). A novel CMFR-AuNPs was synthesized using the developed CMFR as a stabilizing and reducing agent. The antibacterial, antioxidant, and in-vitro anticancer activities were investigated by using CMFR-AuNPs and CMFR - AuNPs@DOX. CMFR-AuNPs demonstrated antioxidative properties by quenching DPPH radicals effectively. CMFR-AuNPs and DOX@CMFR-AuNPs demonstrated strong antibacterial activity against K. pneumoniae, S. aureus, B. subtilis, and E. coli. The cell viability was tested for CMFR -AuNPs at various concentrations of Dox-loaded CMFR -AuNPs (CMFR-AuNPs + Dox1, CMFR-AuNPs + Dox 2, & CMFR-AuNPs + Dox 3). The highest inhibition was observed on MCF-7 and HeLa cell lines using CMFR-AuNPs + Dox 3, respectively. Various techniques such as UV, FTIR, TGA, XRD, SEM, EDAX and TEM were used to characterize the designed CMFR and CMFR-AuNPs. After carboxy methylation, the amorphous nature of FR changed to crystallinity, as reflected in the XRD spectra. The XRD spectrum of the CMFR- AuNPs showed FCC structure due to the involvement of hydroxyl and carboxylic functional groups of CMFR strongly bound with the AuNPs. TGA results revealed that the CMFR is thermally more stable than FR. TEM revealed that CMFR - AuNPs were well dispersed, spherical, and hexagonal with an average diameter of 7 to 10 nm, while the size of doxorubicin loaded (DOX@CMFR-AuNPs) AuNPs was 11 to 13 nm. Green CMFR-AuNPs have the potential to enhance the drug loading and anticancer efficacy of drugs.Copyright © 2024. Published by Elsevier B.V.