肥胖和癌症因其患病率较高而成为世界各地的两大健康问题。多项实验和流行病学研究已经证明了肥胖与癌症之间的关系，其中肥胖被认为是癌症发生的危险因素。了解表观遗传对肥胖与癌症关系的贡献的最终目的是找到干预或治疗肥胖与癌症的方法。因此，有必要提供关于表观遗传对肥胖与癌症之间关系的贡献的最普遍的观点。肥胖与目前遇到的一些常见癌症密切相关，包括乳腺癌、食道癌、肝癌、肾癌、子宫癌、结直肠癌、胰腺癌和胆囊癌。肥胖会增加癌症死亡的风险，从而间接影响治疗的选择。据估计，大约 4-8% 的癌症病例是由肥胖引起的。尤其是了解癌症之间关系的基本机制非常复杂，尚未完全了解。这项工作旨在总结目前关于表观遗传调控在肥胖之间的关系中的作用的知识以及潜在的应用。版权所有 © 2024。由 Elsevier Inc. 出版。

Obesity and cancer are two major health issues all around the world due to their elevated prevalence. Several experimental and epidemiological studies have demonstrated the relationship between obesity and cancer, in which obesity is considered a risk factor for cancer development. The ultimate goal of knowing the epigenetic contribution to the relationship between obesity and cancer is to find the method of intervention or treatment of obesity and cancer. Therefore, providing the most general perspective on epigenetic contribution to the relationship between obesity and cancer is necessary. Obesity is closely related to some common cancers that are currently encountered, including breast, esophagus, liver, kidney, uterus, colorectal, pancreatic, and gallbladder. Obesity has a significant impact that increases the risk of cancer deaths and thereby indirectly affects the choice of treatment. It is estimated that about 4-8% of cancer cases are caused by obesity. In particular, the basic mechanism to understand the relationship between cancer is very complicated and has not been fully understood. This work is aimed at summarizing the current knowledge of the role of epigenetic regulation in the relationship between obesity, and potential applications.Copyright © 2024. Published by Elsevier Inc.