卵巢癌是女性尤其是50岁以上女性死亡率最高的疾病之一。未来，预计人类发展指数较低的国家的发病率和死亡率将会上升。遗传因素结构和功能的不稳定长期以来被认为是癌症（包括卵巢癌）的一个原因。除了了解基因突变之外，表观遗传改变已成为导致卵巢肿瘤发病机制的另一个方面。人们发现这种致命疾病的发生和进展与表观遗传调控异常有关。 DNA 甲基化、组蛋白修饰和基于非编码 RNA 的基因沉默是卵巢癌发展中令人感兴趣的过程，也是癌症检测或治疗的新靶标。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Ovarian cancer is one of the diseases that have the highest mortality rate for women, especially women over 50 years old. In the future, incidence and mortality rates are predicted to extend in countries with low HDI. Instability in the structure and function of genetic factors has long been known as a cause of cancer, including ovarian cancer. Besides understanding gene mutations, epigenetic alterations have emerged as another aspect leading to the pathogenesis of ovarian neoplasm. The development and progression of this fatal disease have been found to be associated with abnormalities of epigenetic regulation. DNA methylation, histone modification, and non-coding RNAs-based gene silencing are processes of interest in developing ovarian carcinoma and are also new targets for cancer detection or treatment.Copyright © 2024 Elsevier Inc. All rights reserved.