人体乳腺组织工程在健康与疾病中的应用
Human breast tissue engineering in health and disease
DOI 原文链接
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影响因子:8.3
分区:医学1区 Top / 医学：研究与实验1区
发表日期:2024 Oct
作者:
Maj-Britt Buchholz, Demi I Scheerman, Riccardo Levato, Ellen J Wehrens, Anne C Rios
DOI:
10.1038/s44321-024-00112-3
摘要
人类乳腺是一种高度组织化且动态变化的组织，具有产后发育周期的独特特征。在妊娠和哺乳期间，乳腺经历激素驱动的结构重塑，最终形成乳汁产生的特殊结构以养育后代。此外，乳腺疾病的高发率，特别是乳腺癌，也带来重要的健康影响。因此，深入了解乳腺的独特生物学对乳腺癌的管理和妇幼健康具有重要意义。组织工程技术有望缩小现有乳腺模型与临床结果之间的转化差距。本文概述了乳腺组织工程的现状，提出关键需求和面临的挑战，以实现更具预测性的乳腺模型。我们还提出了验证乳腺功能的方法，并强调其在乳腺癌改善理解和靶向中的临床前应用。超越乳腺生理学，具有代表性的人类乳腺模型还能提供有关干细胞生物学和发育过程的全新见解，这些研究成果可扩展到其他器官和临床背景。
Abstract
The human mammary gland represents a highly organized and dynamic tissue, uniquely characterized by postnatal developmental cycles. During pregnancy and lactation, it undergoes extensive hormone-stimulated architectural remodeling, culminating in the formation of specialized structures for milk production to nourish offspring. Moreover, it carries significant health implications, due to the high prevalence of breast cancer. Therefore, gaining insight into the unique biology of the mammary gland can have implications for managing breast cancer and promoting the well-being of both women and infants. Tissue engineering techniques hold promise to narrow the translational gap between existing breast models and clinical outcomes. Here, we provide an overview of the current landscape of breast tissue engineering, outline key requirements, and the challenges to overcome for achieving more predictive human breast models. We propose methods to validate breast function and highlight preclinical applications for improved understanding and targeting of breast cancer. Beyond mammary gland physiology, representative human breast models can offer new insight into stem cell biology and developmental processes that could extend to other organs and clinical contexts.