嵌合抗原受体 T 细胞 (CAR-T) 免疫疗法已成为癌症研究的热门领域，在难治性和复发性血液恶性肿瘤中展现出革命性的疗效。然而，CAR-T疗法仍面临严峻挑战，包括生产流程复杂冗长、靶向递送效果不佳、实体瘤治疗效果有限、体内实时监测困难等。为了克服这些限制，各种多功能生物材料已被用于上述方面，并显着改善了 CAR-T 疗法。本综述主要总结了生物材料在制造、增强靶向递送和肿瘤浸润以及显着的体内追踪等方面促进CAR-T治疗的最新研究进展，为临床治疗提供新的见解和启发。版权所有©2024作者。由爱思唯尔有限公司出版。保留所有权利。

Chimeric antigen receptor T cell (CAR-T) immunotherapy has become a heated field of cancer research, demonstrating revolutionary efficacy in refractory and relapsed hematologic malignancies. However, CAR-T therapy has still encountered tough challenges, including complicated and lengthy manufacturing procedures, mediocre targeted delivery, limited therapeutic effect against solid tumors and difficulties in real-time in vivo monitoring. To overcome these limitations, various versatile biomaterials have been used in the above aspects and have improved CAR-T therapy impressively. This review mainly summarizes the latest research progress of biomaterials promoting CAR-T therapy in manufacturing, enhancing targeted delivery and tumor infiltration, and dramatic in vivo tracking to provide new insights and inspiration for clinical treatment.Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.