非壶腹部十二指肠腺癌 (NDA) 约占所有胃肠道癌症的 5%。完全手术切除（R0）并切除区域引流淋巴结是治疗非壶腹十二指肠癌或实现长期生存的强制性治疗方法。根据现有文献，微创手术已被报道在胰十二指肠切除术中是安全的且在肿瘤学上等效。胰腺癌和十二指肠癌。我们描述了一种完全腹腔镜手术治疗十二指肠左侧腺癌“左侧”是参考肠系膜血管（III-IV段）来定义的。这篇多媒体论文在文献中首次描述了一种完全腹腔镜完整的方法十二指肠左侧（III-IV 段）切除 (R0) 和局部淋巴结切除。使用安全批判性观点的概念描述了该过程的主要步骤。完全体内吻合术确保了肠道连续性的重建。通过本文中介绍的技巧和适应症，我们为微创方法提供了指南，并提高了手术外科医生对这种复杂手术的熟悉程度。© 2024。外科肿瘤学会。

Nonampullary duodenal adenocarcinoma (NDA) accounts for approximately 5% of all gastrointestinal cancers. Complete surgical resection (R0) with regional draining lymph node removal is mandatory as treatment to potentially cure nonampullary duodenal cancer or to achieve long-term survival.According to existing literature, minimally invasive surgery has been reported to be safe and oncologically equivalent in pancreaticoduodenectomy for pancreatic and duodenal cancer. We describe a fully laparoscopic approach for the left-side adenocarcinoma of the duodenum "left-side" is defined with reference to the mesenteric vessels (III-IV segment).For the first time in literature, this multimedia paper describes a fully laparoscopic complete resection (R0) of the left side of the duodenum (III-IV segment) with locoregional lymph node resection. The main steps of the procedure are described using the concept of the critical view of safety. Reconstruction of intestinal continuity was ensured by full intracorporeal anastomosis.Through the tips and indications presented in this article, we supply a guide to the minimally invasive approach and increase operating surgeons' familiarity with such a complex procedure.© 2024. Society of Surgical Oncology.