细菌衍生物介导的药物递送在癌症治疗中的应用：新一代策略
Bacterial derivatives mediated drug delivery in cancer therapy: a new generation strategy
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影响因子:12.6
分区:生物学1区 Top / 生物工程与应用微生物1区 纳米科技2区
发表日期:2024 Aug 24
作者:
Muhammad Ijaz, Ikram Hasan, Tamoor Hamid Chaudhry, Rui Huang, Lan Zhang, Ziwei Hu, Qingqin Tan, Bing Guo
DOI:
10.1186/s12951-024-02786-w
摘要
癌症是危及人类生命的主要威胁之一，也是死亡的主要原因。每年有数百万癌症患者死亡，尽管大量研究人员不断努力开发抗癌药物以对抗癌症。由于癌症的复杂性和异质性、难以深入治疗的肿瘤组织以及对正常细胞的高毒性，癌症治疗变得异常复杂。然而，细菌衍生物介导的药物递送引起了研究者的兴趣，旨在克服传统癌症化疗的限制。在本综述中，我们展示了多种肿瘤靶向细菌及细菌衍生物在抗癌药物递送中的应用实例。本文还描述了利用这些肿瘤靶向细菌及其膜泡在受控条件下递送抗癌药物的优势与局限性。这项研究强调了细菌基础药物载体在临床转化中的巨大潜力，提升其与其他治疗方式结合的能力，并提供更强大、可靠且独特的肿瘤治疗策略。
Abstract
Cancer is measured as a major threat to human life and is a leading cause of death. Millions of cancer patients die every year, although a burgeoning number of researchers have been making tremendous efforts to develop cancer medicine to fight against cancer. Owing to the complexity and heterogeneity of cancer, lack of ability to treat deep tumor tissues, and high toxicity to the normal cells, it complicates the therapy of cancer. However, bacterial derivative-mediated drug delivery has raised the interest of researchers in overcoming the restrictions of conventional cancer chemotherapy. In this review, we show various examples of tumor-targeting bacteria and bacterial derivatives for the delivery of anticancer drugs. This review also describes the advantages and limitations of delivering anticancer treatment drugs under regulated conditions employing these tumor-targeting bacteria and their membrane vesicles. This study highlights the substantial potential for clinical translation of bacterial-based drug carriers, improve their ability to work with other treatment modalities, and provide a more powerful, dependable, and distinctive tumor therapy.