细菌衍生物介导的癌症治疗中的药物输送：新一代策略
Bacterial derivatives mediated drug delivery in cancer therapy: a new generation strategy
影响因子:12.60000
分区:生物学1区 Top / 生物工程与应用微生物1区 纳米科技2区
发表日期:2024 Aug 24
作者:
Muhammad Ijaz, Ikram Hasan, Tamoor Hamid Chaudhry, Rui Huang, Lan Zhang, Ziwei Hu, Qingqin Tan, Bing Guo
摘要
癌症是对人类生命的主要威胁，是死亡的主要原因。每年数以百万计的癌症患者死亡，尽管许多迅速发展的研究人员一直在做出巨大的努力来开发癌症医学以对抗癌症。由于癌症的复杂性和异质性，缺乏治疗深肿瘤组织的能力以及对正常细胞的高毒性，它使癌症的治疗变得复杂。然而，细菌衍生物介导的药物输送增加了研究人员在克服常规癌症化疗的限制方面的兴趣。在这篇综述中，我们展示了针对肿瘤的细菌和细菌衍生物的各种例子，用于递送抗癌药物。这篇综述还描述了采用这些靶向肿瘤的细菌及其膜囊泡在受调节状况下输送抗癌治疗药物的优势和局限性。这项研究强调了基于细菌的药物载体临床翻译的巨大潜力，提高了其与其他治疗方式合作的能力，并提供了更强大，可靠和独特的肿瘤疗法。
Abstract
Cancer is measured as a major threat to human life and is a leading cause of death. Millions of cancer patients die every year, although a burgeoning number of researchers have been making tremendous efforts to develop cancer medicine to fight against cancer. Owing to the complexity and heterogeneity of cancer, lack of ability to treat deep tumor tissues, and high toxicity to the normal cells, it complicates the therapy of cancer. However, bacterial derivative-mediated drug delivery has raised the interest of researchers in overcoming the restrictions of conventional cancer chemotherapy. In this review, we show various examples of tumor-targeting bacteria and bacterial derivatives for the delivery of anticancer drugs. This review also describes the advantages and limitations of delivering anticancer treatment drugs under regulated conditions employing these tumor-targeting bacteria and their membrane vesicles. This study highlights the substantial potential for clinical translation of bacterial-based drug carriers, improve their ability to work with other treatment modalities, and provide a more powerful, dependable, and distinctive tumor therapy.