研究动态
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妇科恶性肿瘤患者的身体成分和围手术期和术后并发症:系统评价。

Body composition and peri- and postoperative complications in patients with gynaecological malignancies: A systematic review.

发表日期:2024 Aug 24
作者: C Heus, S Stelten, G G Kenter, L M Buffart, L R C W van Lonkhuijzen
来源: GYNECOLOGIC ONCOLOGY

摘要:

在一般腹部手术中,脂肪与肌肉质量的比率或身体成分测量值比体重指数与并发症的相关性更强。这些研究包括男性和女性患者。女性的身体成分与男性不同。因此,普通腹部手术的结果不能推断到患有癌症的女性。本系统综述的目的是总结妇科癌症患者身体成分与围手术期和术后并发症之间关联的证据。于 2023 年 6 月检索了 Pubmed、Embase 和 Cochrane Central 数据库。如果研究纳入患者,则研究合格。接受妇科癌症手术,并报告了身体成分(肌肉或脂肪量)与手术并发症之间的关联。使用纽卡斯尔-渥太华质量评估量表评估研究的质量。使用最佳证据综合来总结证据水平。纳入了十五项评估肌肉质量 (n = 9) 或脂肪质量 (n = 6) 的研究。我们发现强有力的证据表明内脏脂肪与住院时间之间没有关联。我们发现了适度的证据表明,较高质量的肌肉数量与较低的术后并发症风险相关。我们发现中等证据表明肌肉或脂肪量(即肌肉或皮下脂肪)与术后并发症或脂肪量与术中并发症之间没有关联。没有足够的证据证明内脏脂肪与术中或术后并发症之间的关联,以及肌肉质量或质量与住院时间之间的关联。用于测量身体成分的方法存在高度异质性,阻碍了荟萃分析。身体成分(特别是脂肪组织和肌肉质量)与并发症之间的关联表明,这些措施可能有助于确定接受手术的女性的术后风险。妇科癌症。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。
In general abdominal surgery, the ratio of fat to muscle mass, or body composition measures, shows a stronger association with complications than body mass index. These studies include male and female patients. Women have a different body composition than men. Therefore, findings from general abdominal surgery cannot be extrapolated to women with cancer. The aim of this systematic review is to summarise the evidence on the association between body composition and peri- and postoperative complications in patients with gynaecological cancer.Pubmed, Embase and the Cochrane Central databases were searched in June 2023. Studies were eligible if they included patients undergoing surgery for gynaecological cancer and reported on the association between body composition (muscle or fat mass) and surgical complications. The quality of the studies was assessed using the Newcastle-Ottawa quality assessment scale. A best-evidence synthesis was used to summarise the level of evidence.Fifteen studies were included that assessed muscle mass (n = 9) or fat mass (n = 6). We found strong evidence that there was no association between visceral fat and length of hospital stay. We found moderate evidence that a higher amount of good quality muscle was associated with a lower risk of postoperative complications. We found moderate evidence that there was no association between muscle or fat mass (i.e., muscle- or subcutaneous fat) and postoperative complications or fat mass and intraoperative complications. There was insufficient evidence for an association between visceral fat and intraoperative or postoperative complications, and for an association between muscle mass or -quality and length of hospital stay. There was high heterogeneity in the methods used to measure body composition, hampering meta-analyses.The association between body composition, particularly adipose tissue and muscle quality, and complications suggests that these measures may be of interest in determining postoperative risk in women undergoing surgery for gynaecological cancer.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.