儿童癌幸存者的角质形成细胞癌：儿童癌症幸存者研究的报告
Keratinocyte carcinomas in survivors of childhood cancer: A report from the childhood cancer survivor study
影响因子:11.80000
分区:医学1区 Top / 皮肤病学1区
发表日期:2024 Dec
作者:
Christina Boull, Yan Chen, Cindy Im, Alan Geller, Yadav Sapkota, James E Bates, Rebecca Howell, Michael A Arnold, Miriam Conces, Louis S Constine, Leslie Robison, Yutaka Yasui, Gregory T Armstrong, Joseph P Neglia, Lucie M Turcotte
摘要
儿童癌症幸存者（CCS）的角色癌（KC）的风险增加，但是，单个和多个KC的长期发病率尚未得到很好的确定。识别危险因素并量化Kc累积的发生率，在CCS.KC中确定了1990年诊断的CCS.KC的CCS.KC的多重症状<1990年<1990年诊断的CCS.KC，<1990年<199岁的儿童生存者<1990年以来，< 美国。 Cumulative incidence was estimated and multivariable models assessed relative rates of KC associated with survivor and treatment characteristics.Among 25,658 participants, 1446 developed 5363 KC (93.5% basal cell carcinoma, 6.7% squamous cell carcinoma; mean age 37.0 years (range 7.3-67.4), mean latency 25.7 years; 95.3% White and 88.4% with放射疗法）。平均病变计数为3.7，26.1％的经历≥4。放射疗法的任何KC速率增加了4.5倍，≥4kc的速率增加了9.4倍。同种异体和自体造血细胞移植分别与KC的3.4-和2.3倍增加相关。参与者对某些数据的自我报告，包括没有皮肤光谱和过去病史的种族和过去病史的分析可能会影响分析。CC的负担仍然很高，但可预测的可预测的风险因素应引导筛查。
Abstract
Childhood cancer survivors (CCS) are at increased risk for keratinocyte carcinomas (KC) however, the long-term incidence of single and multiple KC is not well established.Identify risk factors and quantify KC cumulative incidence and multiple-incidence burden in CCS.KC were identified among Childhood Cancer Survivor Study participants, a cohort of 5-year cancer survivors diagnosed <21 years of age between 1970 and 1999 in North America. Cumulative incidence was estimated and multivariable models assessed relative rates of KC associated with survivor and treatment characteristics.Among 25,658 participants, 1446 developed 5363 KC (93.5% basal cell carcinoma, 6.7% squamous cell carcinoma; mean age 37.0 years (range 7.3-67.4), mean latency 25.7 years; 95.3% White and 88.4% with radiotherapy). Mean lesion count was 3.7 with 26.1% experiencing ≥4. Radiotherapy imparted a 4.5-fold increase in the rate of any KC and 9.4-fold increase in the rate of ≥4 KC. Allogeneic and autologous hematopoietic cell transplant were associated with a 3.4- and 2.3-fold increased rate of KC, respectively.Participant self-reporting of some data including race without skin phototype and past medical history may have impacted analysis.The burden of KC in CCS remains high, but predictable risk factors should guide screening.