揭示通过羧甲基纤维素提取制备的钴氧化物纳米颗粒的多样生物活性
Unveiling the diverse bioactivity of cobalt oxide nanoparticles produced through carboxymethyl cellulose extraction
DOI 原文链接
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影响因子:8.5
分区:生物学2区 Top / 生化与分子生物学2区 应用化学2区 高分子科学2区
发表日期:2024 Nov
作者:
Sohad Abdulkaleg Alshareef, Aishah E Albalawi
DOI:
10.1016/j.ijbiomac.2024.135028
摘要
本研究探索了一种环保的合成方法，利用提取的羧甲基纤维素（CMC）作为还原剂和稳定剂合成钴氧化物纳米颗粒（Co3O4NPs）。通过多种分析手段对Co3O4NPs进行了表征，显示其具有晶体结构，粒径范围为10.9至28.2 nm。显微成像确认其具有均匀的球形形态，平均直径为27.2 nm。对Co3O4NPs的生物活性进行了广泛研究，突出其优异的抗菌效果，优于阿莫西林-克拉维酸。该纳米颗粒表现出强大的抗氧化性，并基于红细胞存活率结果显示其具有潜在的安全性。此外，Co3O4NPs对Michigan癌症基金会-7（MCF-7）乳腺癌细胞表现出显著的抗癌活性，并在α-淀粉酶抑制活性方面显示出有前景的多功能治疗潜能，具备抗氧化、抗菌、抗癌和α-淀粉酶抑制等作用。
Abstract
This study explores an eco-friendly method for synthesizing Cobalt oxide nanoparticles (Co3O4NPs) using extracted carboxymethyl cellulose (CMC) as a reducing and stabilizing agent. The Co3O4NPs, characterized via various analyses, demonstrated a crystalline structure with sizes ranging from 10.9 to 28.2 nm. Microscopic imaging confirmed a uniform spherical morphology with an average diameter of 27.2 nm. The biological activities of Co3O4NPs were investigated extensively, highlighting their superior antibacterial efficacy compared to amoxicillin-clavulanic acid. These nanoparticles exhibited potent antioxidant properties and demonstrated safety for potential applications based on erythrocyte viability results. Additionally, Co3O4NPs displayed significant potency against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and showed promising α-amylase enzyme inhibitory activity, highlighting their multifunctional therapeutic potential as antioxidant, antibacterial, anticancer, and alpha-amylase inhibition assay.