揭示通过羧甲基纤维素提取产生的氧化钴纳米颗粒的多种生物活性
Unveiling the diverse bioactivity of cobalt oxide nanoparticles produced through carboxymethyl cellulose extraction
影响因子:8.50000
分区:生物学2区 Top / 生化与分子生物学2区 应用化学2区 高分子科学2区
发表日期:2024 Nov
作者:
Sohad Abdulkaleg Alshareef, Aishah E Albalawi
摘要
这项研究探讨了一种使用提取的羧甲基纤维素（CMC）作为还原和稳定剂合成氧化钴纳米颗粒（CO3O4NP）的环保方法。通过各种分析表征的CO3O4NP显示了晶体结构，大小范围为10.9至28.2 nm。微观成像证实了均匀的球形形态，平均直径为27.2 nm。对CO3O4NP的生物学活性进行了广泛的研究，与阿莫西林 - 克拉维酸相比，强调了它们的优质抗菌功效。这些纳米颗粒表现出有效的抗氧化特性，并根据红细胞生存力结果证明了潜在应用的安全性。此外，CO3O4NP对密歇根州癌症基础7（MCF-7）乳腺癌细胞表现出明显的效力，并显示出令人鼓舞的α-淀粉酶抑制活性，突出了其多功能治疗潜力，例如抗氧化剂，抗杆菌，抗体，抗癌，抗癌，和α-氨基酶抑制剂。
Abstract
This study explores an eco-friendly method for synthesizing Cobalt oxide nanoparticles (Co3O4NPs) using extracted carboxymethyl cellulose (CMC) as a reducing and stabilizing agent. The Co3O4NPs, characterized via various analyses, demonstrated a crystalline structure with sizes ranging from 10.9 to 28.2 nm. Microscopic imaging confirmed a uniform spherical morphology with an average diameter of 27.2 nm. The biological activities of Co3O4NPs were investigated extensively, highlighting their superior antibacterial efficacy compared to amoxicillin-clavulanic acid. These nanoparticles exhibited potent antioxidant properties and demonstrated safety for potential applications based on erythrocyte viability results. Additionally, Co3O4NPs displayed significant potency against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells and showed promising α-amylase enzyme inhibitory activity, highlighting their multifunctional therapeutic potential as antioxidant, antibacterial, anticancer, and alpha-amylase inhibition assay.