抑制素βB亚基（INHBB）基因编码抑制素βB亚基，该亚基参与形成转化生长因子-β（TGF-β）超家族的蛋白质成员。 TGF-β超家族广泛参与细胞增殖、分化、粘附、运动、代谢、通讯和死亡。激活素和抑制素属于 TGF-β 超家族，首先在卵巢卵泡液中发现。它们最初被描述为体内和体外垂体促卵泡激素（FSH）分泌的调节剂。后来的研究发现，INHBB不仅在卵巢、子宫和睾丸等生殖器官中表达，而且在许多其他器官中表达，包括大脑、脊髓、肝脏、肾脏和肾上腺。这种广泛的分布意味着它参与各个器官的正常生理功能；然而，这些功能的机制尚未完全阐明。最近的研究表明，INHBB 在肿瘤发生中发挥着重要而复杂的作用。它似乎具有双重作用，在某些情况下促进肿瘤进展，而在另一些情况下抑制肿瘤进展，尽管这些作用尚未完全了解。在本文中，我们回顾了 INHBB 在正常组织和肿瘤组织中的不同表达模式、功能和机制，以阐明 INHBB 在肿瘤进展中的研究前景。© 2024。作者获得纳瓦拉大学独家许可。

The gene inhibin subunit beta B (INHBB) encodes the inhibin βB subunit, which is involved in forming protein members of the transforming growth factor-β (TGF-β) superfamily. The TGF-β superfamily is extensively involved in cell proliferation, differentiation, adhesion, movement, metabolism, communication, and death. Activins and inhibins, which belong to the TGF-β superfamily, were first discovered in ovarian follicular fluid. They were initially described as regulators of pituitary follicle-stimulating hormone (FSH) secretion both in vivo and in vitro. Later studies found that INHBB is expressed not only in reproductive organs such as the ovary, uterus, and testis but also in numerous other organs, including the brain, spinal cord, liver, kidneys, and adrenal glands. This wide distribution implies its involvement in the normal physiological functions of various organs; however, the mechanisms underlying these functions have not yet been fully elucidated. Recent studies suggest that INHBB plays a significant, yet complex role in tumorigenesis. It appears to have dual effects, promoting tumor progression in some contexts while inhibiting it in others, although these roles are not yet fully understood. In this paper, we review the different expression patterns, functions, and mechanisms of INHBB in normal and tumor tissues to illustrate the research prospects of INHBB in tumor progression.© 2024. The Author(s) under exclusive licence to University of Navarra.